ArticleBMC medicine2023
Genetic susceptibility and lifestyle modify the association of long-term air pollution exposure on major depressive disorder: a prospective study in UK Biobank.
Article in BMC medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 43 citations in OpenAlex.
- Prospective Metabolomic Cohort of 123,037 Men Reveals Lipid Mediators Linking Air Pollution to Benign Prostatic Hyperplasia.Environment & health (Washington, D.C.) · 2026Article
- The Relationship between Air Pollution Exposure, Genetic Liability for Schizophrenia, and Brain Outcomes in the ABCD Study.Schizophrenia bulletin · 2026Article
- Healthy Lifestyle and Time to Depression Onset in Individuals With and Without Incident Stroke: A Longitudinal Analysis Using UK Biobank Data.Alpha psychiatry · 2026Article
- The Relationship Between Blood Lipids, Coagulation Indexes, Blood Homocysteine and Sudden Deafness: A Retrospective Study and Mendelian Randomization Analysis.World journal of otorhinolaryngology - head and neck surgery · 2026Article
- Chronotype, Genetic Risk, Lifestyle, and Risk of Depression and Anxiety: A Prospective Cohort Study.MedComm · 2026Article
- Article
- Optimization of potential targets for antidepressant Chinese medicines: AI and multi-omics methods.Chinese medicine · 2026Review
- Joint effect of exposure to fine particulate matter and lifestyle risk factors on depression and anxiety among Chinese adolescents: a national school-based study in China.Epidemiology and psychiatric sciences · 2025Article
- Identifying modifiable factors and their joint associations on late-onset schizophrenia risk in the UK Biobank: a prospective exposure-wide association study.BMJ mental health · 2025Article
- Review
- Regular sleep patterns, not just duration, critical for mental health: association of accelerometer-derived sleep regularity with incident depression and anxiety.Psychological medicine · 2025Article
- Effects of polygenic risk for major depressive disorder and childhood emotional neglect on cortical blood flow complexity in young depression patients.Brain imaging and behavior · 2025Article
- Associations between air pollution and surrounding greenness with internalizing and externalizing behaviors among schoolchildren.Child and adolescent mental health · 2025Article
- Exploring genetic susceptibility to air pollution and its implications for disease risk and precision health: A scoping review.AIMS public health · 2025Review
- Long-term ambient air pollution and the risk of major mental disorder: A prospective cohort study.European psychiatry : the journal of the Association of European Psychiatrists · 2024Article
- Linking ambient air pollution to mental health: evidence based on the two-sample Mendelian randomization and colocalization study.Translational psychiatry · 2024Article
- Exposure to Air Pollution, Genetic Susceptibility, and Psoriasis Risk in the UK.JAMA network open · 2024Article
- Genetic susceptibility modifies the association of long-term air pollution exposure on Parkinson's disease.NPJ Parkinson's disease · 2024Article
- Interaction between the oxidative balance score and serum per- and poly-fluoroalkyl substances (PFASs) on liver health: analysis of the NHANES 2007-2018 dataset.Environmental health and preventive medicine · 2024Article
- Reduced Vrk2 expression is associated with higher risk of depression in humans and mediates depressive-like behaviors in mice.BMC medicine · 2023Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEvidence linking air pollution to major depressive disorder (MDD) remains sparse and results are heterogeneous. In addition, the evidence about the interaction and joint associations of genetic risk and lifestyle with air pollution on incident MDD risk remains unclear. We aimed to examine the association of various air pollutants with the risk of incident MDD and assessed whether genetic susceptibility and lifestyle influence the associations.
methodsThis population-based prospective cohort study analyzed data collected between March 2006 and October 2010 from 354,897 participants aged 37 to 73 years from the UK Biobank. Annual average concentrations of PM
resultsDuring a median follow-up of 9.7 years (3,427,084 person-years), 14,710 incident MDD events were ascertained. PM
conclusionsLong-term exposure to air pollution is associated with MDD risk. Identifying individuals with high genetic risk and developing healthy lifestyle for reducing the harm of air pollution to public mental health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.