Evidence map›Paper›PMID 36810074›Full record

ArticleJournal of nanobiotechnology2023

Biodegradable nanoplatform upregulates tumor microenvironment acidity for enhanced cancer therapy via synergistic induction of apoptosis, ferroptosis, and anti-angiogenesis.

Caiyun Zhang, Peng Wang, Ya' Nan Zhang, Pengpeng Lu, Xiaodan Huang, Yinfeng Wang, Lang Ran, Huan Xin, Xiaotong Xu, Wenjuan Gao and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Caiyun ZhangSchool of Pharmacy, Shandong Technology Innovation Center of Molecular Targeting and Intelligent Diagnosis and Treatment, Binzhou Medical University, Yantai, 264003, People's Republic of China.
Peng WangSchool of Pharmacy, Shandong Technology Innovation Center of Molecular Targeting and Intelligent Diagnosis and Treatment, Binzhou Medical University, Yantai, 264003, People's Republic of China.
Ya' Nan ZhangSchool of Pharmacy, Shandong Technology Innovation Center of Molecular Targeting and Intelligent Diagnosis and Treatment, Binzhou Medical University, Yantai, 264003, People's Republic of China.
Pengpeng LuSchool of Pharmacy, Shandong Technology Innovation Center of Molecular Targeting and Intelligent Diagnosis and Treatment, Binzhou Medical University, Yantai, 264003, People's Republic of China.
Xiaodan HuangSchool of Pharmacy, Shandong Technology Innovation Center of Molecular Targeting and Intelligent Diagnosis and Treatment, Binzhou Medical University, Yantai, 264003, People's Republic of China.
Yinfeng WangSchool of Pharmacy, Shandong Technology Innovation Center of Molecular Targeting and Intelligent Diagnosis and Treatment, Binzhou Medical University, Yantai, 264003, People's Republic of China.
Lang RanSchool of Pharmacy, Shandong Technology Innovation Center of Molecular Targeting and Intelligent Diagnosis and Treatment, Binzhou Medical University, Yantai, 264003, People's Republic of China.
Huan XinSchool of Pharmacy, Shandong Technology Innovation Center of Molecular Targeting and Intelligent Diagnosis and Treatment, Binzhou Medical University, Yantai, 264003, People's Republic of China.
Xiaotong XuSchool of Pharmacy, Shandong Technology Innovation Center of Molecular Targeting and Intelligent Diagnosis and Treatment, Binzhou Medical University, Yantai, 264003, People's Republic of China.
Wenjuan GaoSchool of Pharmacy, Shandong Technology Innovation Center of Molecular Targeting and Intelligent Diagnosis and Treatment, Binzhou Medical University, Yantai, 264003, People's Republic of China.
Yu SunInstitute of Aging Medicine, Binzhou Medical University, Yantai, 264003, Shandong, China. sunyu@sibs.ac.cn.
Li ZhangDepartment of Urology, the First Affiliated Hospital of Anhui Medical University, Institute of Urology, Anhui Medical University and Anhui Province Key Laboratory of Genitourinary Diseases, Anhui Medical University, Hefei, 230022, Anhui, People's Republic of China. lzhang@ahmu.edu.cn.
Guilong ZhangSchool of Pharmacy, Shandong Technology Innovation Center of Molecular Targeting and Intelligent Diagnosis and Treatment, Binzhou Medical University, Yantai, 264003, People's Republic of China. glzhang@bzmc.edu.cn.
Binzhou Medical University · CNBinzhou University · CNAnhui Medical University · CN

Funding

Binzhou Medical University BY2019KYQD17National Natural Science Foundation of China 22007006Natural Science Foundation of Shandong Province ZR2020QB102Special Project of Central Government for Local Science and Technology Development of Shandong Province YDZX20203700001291Taishan Scholars Construction Engineering tsqn201909144
6 · The paper itself

Abstract

Chemodynamic therapy of cancer is limited by insufficient endogenous H

Indexed as

FerroptosisNeoplasmsApoptosisCell Line, TumorGlucose OxidaseHumansHydrogen PeroxideTumor MicroenvironmentGlucose OxidaseHydrogen PeroxideBiodegradable nanoplatformEnhanced chemodynamic therapyIncreased acidityStarvation therapyTumor microenvironment

Identifiers

PMID36810074
PMCPMC9945394
OpenAlexW4321433979

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.