Evidence map›Paper›PMID 36812308›Full record

ArticleScience advances2023

Asprosin promotes feeding through SK channel-dependent activation of AgRP neurons.

Bing Feng, Hesong Liu, Ila Mishra, Clemens Duerrschmid, Peiyu Gao, Pingwen Xu, Chunmei Wang, Yanlin He

Open access · goldAbstract read
In one paragraph

Article in Science advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 31 citations in OpenAlex.

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  14. The cerebellum modulates thirst.Nature neuroscience · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Bing FengPennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, USA.ORCID 0000-0002-7403-8402
Hesong LiuUSDA-ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0003-3768-1463
Ila MishraHarrington Discovery Institute, Cleveland, OH, USA.ORCID 0000-0002-9786-6358
Clemens DuerrschmidDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0001-7718-5152
Peiyu GaoPennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, USA.
Pingwen XuDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, The University of Illinois at Chicago, Chicago, IL, USA.ORCID 0000-0001-9363-4114
Chunmei WangUSDA-ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0001-8104-6892
Yanlin HePennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, USA.ORCID 0000-0002-5471-9016
Pennington Biomedical Research Center · USChildren's Nutrition Research Center at Baylor College of Medicine · USBaylor College of Medicine · USDiscovery Laboratories (United States) · USUniversity of Illinois Chicago · US

Funding

Research BaseP30DK072476 · NIDDK · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI ROBERT A KESTERSON · 2005 to 2026
$26.5M
Pilot and Feasibility ProgramP30DK020595 · NIDDK · UNIVERSITY OF CHICAGO · PI RONALD N COHEN · 2013 to 2026
$20.9M
The role of maternal obesity-driven inflammation and adverse pregnancy outcomes in a mouse model of preeclampsiaP20GM135002 · NIGMS · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Christopher D Morrison · 2020 to 2026
$18.4M
Testosterone and estrogen signaling pathways in the medial amygdala interact to control energy homeostasisR01DK123098 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI XU, PINGWEN · 2020 to 2024
$2.5M
GABA neurons in the ventromedial hypothalamus contribute to the counterregulatory responseR01DK129548 · NIDDK · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Yanlin He · 2022 to 2026
$2.1M
A TAP63 TRANSCRIPTIONAL AXIS CONTRIBUTES TO THE SEXUAL DIMORPHISM IN POMC NEURON FUNCTIONS AND ENERGY HOMEOSTASISK01DK119471 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI WANG, CHUNMEI · 2019 to 2021
$391k
NIDDK NIH HHS K01 DK119471NIDDK NIH HHS P30 DK020595NIDDK NIH HHS P30 DK072476NIDDK NIH HHS R01 DK123098NIDDK NIH HHS R01 DK129548NIGMS NIH HHS P20 GM135002
6 · The paper itself

Abstract

Asprosin, a recently identified adipokine, activates agouti-related peptide (AgRP) neurons in the arcuate nucleus of the hypothalamus (ARH) via binding to protein tyrosine phosphatase receptor δ (Ptprd) to increase food intake. However, the intracellular mechanisms responsible for asprosin/Ptprd-mediated activation of AgRP

Indexed as

Arcuate Nucleus of HypothalamusObesityAdipokinesAgouti-Related ProteinFibrillin-1HumansHypothalamusNeuronsAdipokinesAgouti-Related ProteinFBN1 protein, humanFibrillin-1

Identifiers

PMID36812308
PMCPMC9946352
OpenAlexW4321481513

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.