ArticleScience translational medicine2023
Oral mucosal breaks trigger anti-citrullinated bacterial and human protein antibody responses in rheumatoid arthritis.
Registry-linked trialOpen access · greenAbstract read
In one paragraph
Article in Science translational medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02051114 (Discovering the Antecedents of Rheumatoid Arthritis Flare), which is not on this map. Cited by 63 papers, 4 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 4 pooled it
23.4field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Discovering the Antecedents of Rheumatoid Arthritis Flare
Who cites it
63 citing papers in PubMed, 4 syntheses or guidelines pooled it, 94 citations in OpenAlex.
- Coordinated oral-gut microbiota relocation in connective tissue diseases: a systematic review.Frontiers in immunology · 2026Pooled it
- Multimorbidity patterns of dental caries and obesity/overweight among adults: a systematic review and meta-analysis.BMC oral health · 2025Pooled it
- Does non-surgical periodontal treatment contribute to rheumatoid arthritis amelioration? Evidence based on an overview and meta-analysis.Odontology · 2025Pooled it
- Bibliometric and visualized analysis of the relationship between rheumatoid arthritis and periodontitis-related bacteria using CiteSpace software.Frontiers in microbiology · 2025Pooled it
- Anti-gingipain antibodies and ACE1 activity in rheumatoid arthritis: associations with disease activity and cardiovascular comorbidity in a cross-sectional study.Rheumatology international · 2026Article
- Neutrophil Extracellular Trap Formation-Derived Peptidylarginine Deiminases in the Citrullination of Oral Bacteria to Promote Inflammation in Rheumatoid Arthritis.The Journal of rheumatology · 2026Article
- Signaling Pathway-Biomarker Coupling for Precision Therapy in Rheumatoid Arthritis: Mechanistic Insights, Translational Bottlenecks, and Emerging Strategies.ACR open rheumatology · 2026Review
- Murine and Humanized Mouse Models in Autoimmune Disease Research and Therapeutics Development.Biology · 2026Review
- Cross-presentation of citrullinated antigens drives cytotoxic CD8bioRxiv : the preprint server for biology · 2026Article
- IgA autoantibodies demonstrate a novel mechanism of MuSK myasthenia gravis pathology.Brain : a journal of neurology · 2026Article
- A cross-sectional analysis of the vaginal microenvironment in rheumatoid arthritis.Microbiology spectrum · 2026Article
- Periodontitis and Rheumatoid Arthritis: Shared Pathophysiology, Bidirectional Association, and Therapeutic Implications-A Narrative Review.Healthcare (Basel, Switzerland) · 2026Review
- Novel Biomarker for Rheumatoid Arthritis: Serum Peptidylarginine Deiminase 4-Potentiating Activity in an Anti-Citrullinated Protein Antibody-Positive At-Risk Population.Scandinavian journal of immunology · 2026Article
- The Oral-Gut-Immune-Nutrition Axis in Rheumatoid Arthritis: Molecular Mechanisms and Therapeutic Implications.International journal of molecular sciences · 2026Review
- Periodontal disease-associated oral and gut microbiome changes in female rheumatoid arthritis patients.BMC oral health · 2026Article
- Epigenetic inflammatory memory and periodontal disease: Mechanisms and clinical significance for comorbidities.Journal of periodontology · 2026Review
- Dental plaque microbiota following allogeneic hematopoietic cell transplantation and risk of chronic graft-Haematologica · 2026Article
- Correlation of Oxidative Stress Markers and Nuclear Abnormalities with Clinical Parameters in Individuals with Periodontitis.Dentistry journal · 2026Article
- When ISG15 is involved in inflammation.Frontiers in immunology · 2026Review
- The oral microbiome as a regulatory hub for systemic health: a systematic review of mechanistic links and clinical implications.Journal of oral microbiology · 2026Review
3 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
35 authors at 8 institutions in 2 countries.
R Camille BrewerDivision of Immunology and Rheumatology, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0002-0342-1826
Tobias V LanzDivision of Immunology and Rheumatology, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0001-7106-8801
Caryn R HaleRockefeller University, New York City, NY 10065, USA.ORCID 0000-0002-2860-0994
Gregory D Sepich-PooreDepartment of Bioengineering, University of California San Diego, La Jolla, CA 92093, USA.ORCID 0000-0002-3443-3715
Cameron MartinoDepartment of Pediatrics, University of California San Diego, La Jolla, CA 92093, USA.
Austin D SwaffordCenter for Microbiome Innovation, University of California San Diego, La Jolla, CA 92093, USA.ORCID 0000-0001-5655-8300
Thomas S CarrollBioinformatics Resource Center, Rockefeller University, 1230 York Ave., New York, NY 10065, USA.
Sarah KongpachithDivision of Immunology and Rheumatology, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0002-8462-6881
Lisa K BlumDivision of Immunology and Rheumatology, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0002-7921-8939
Serra E ElliottDivision of Immunology and Rheumatology, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0003-4808-7814
Nathalie E BlachereRockefeller University, New York City, NY 10065, USA.ORCID 0000-0002-5858-6097
Salina ParveenRockefeller University, New York City, NY 10065, USA.ORCID 0000-0002-2698-0575
John FakRockefeller University, New York City, NY 10065, USA.ORCID 0000-0002-7237-4699
Vicky YaoDepartment of Computer Science, Rice University, Houston, TX 77005, USA.
Olga TroyanskayaDepartment of Computer Science, Princeton University, Princeton, NJ 08544, USA.ORCID 0000-0002-5676-5737
Mayu O FrankRockefeller University, New York City, NY 10065, USA.ORCID 0000-0002-5597-4828
Michelle S BloomDivision of Immunology and Rheumatology, Stanford University, Stanford, CA 94305, USA.
Shaghayegh JahanbaniDivision of Immunology and Rheumatology, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0001-7789-4856
Alejandro M GomezDivision of Immunology and Rheumatology, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0003-4415-2615
Radhika IyerDivision of Immunology and Rheumatology, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0003-1287-3995
Nitya S RamadossDivision of Immunology and Rheumatology, Stanford University, Stanford, CA 94305, USA.
Orr SharpeDivision of Immunology and Rheumatology, Stanford University, Stanford, CA 94305, USA.
Sangeetha ChandrasekaranDivision of Rheumatology, University of Colorado Denver, Aurora, CO 80045, USA.ORCID 0000-0002-5144-6315
Lindsay B KelmensonDivision of Rheumatology, University of Colorado Denver, Aurora, CO 80045, USA.ORCID 0000-0002-7809-6722
Qian WangDivision of Immunology and Rheumatology, Stanford University, Stanford, CA 94305, USA.
Heidi WongDivision of Immunology and Rheumatology, Stanford University, Stanford, CA 94305, USA.
Holly L TorresVA Palo Alto Health Care System, Palo Alto, CA 94304, USA.ORCID 0000-0002-8392-457X
Mark WiesenVA Palo Alto Health Care System, Palo Alto, CA 94304, USA.ORCID 0000-0002-3124-9058
Dana T GravesDepartment of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0002-4664-8529
Kevin D DeaneDivision of Rheumatology, University of Colorado Denver, Aurora, CO 80045, USA.ORCID 0000-0003-2211-4861
V Michael HolersDivision of Rheumatology, University of Colorado Denver, Aurora, CO 80045, USA.
Rob KnightDepartment of Bioengineering, University of California San Diego, La Jolla, CA 92093, USA.ORCID 0000-0002-0975-9019
Robert B DarnellRockefeller University, New York City, NY 10065, USA.ORCID 0000-0002-5134-8088
William H RobinsonDivision of Immunology and Rheumatology, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0003-4385-704X
Dana E OrangeRockefeller University, New York City, NY 10065, USA.ORCID 0000-0001-9859-7199
VA Palo Alto Health Care System · USRockefeller University · USUniversity of California San Diego · USUniversity of Colorado Denver · USHoward Hughes Medical Institute · USPrinceton University · USHospital for Special Surgery · USUniversity of Pennsylvania · US
Funding
Using a tonsil organoid system to probe conditions for the induction of protective antibody and T cell responses to influenza.U19AI057229 · NIAID · STANFORD UNIVERSITY · PI Mark Morris Davis · 2003 to 2026
$88.5MDeveloping, Demonstrating, and Disseminating Innovative Programs to Achieve Translational SuccessUL1TR001866 · NCATS · ROCKEFELLER UNIVERSITY · PI COLLER, BARRY, KRUEGER, JAMES G · 2016 to 2025
$40.6MMEDICAL SCIENTIST TRAINING PROGRAMT32GM007198 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHI, NEIL C, INSEL, PAUL A · 1985 to 2024
$29.3MMOLECULAR &CELLULAR IMMUNOBIOLOGYT32AI007290 · NIAID · STANFORD UNIVERSITY · PI Sean Curtis Bendall, Olivia M Martinez · 1985 to 2026
$27.0MPrecision Mapping of Knee Pain in Osteoarthritis: Understanding differences between pain with activity and restUC2AR082186 · NIAMS · RUSH UNIVERSITY MEDICAL CENTER · PI LOTZ, MARTIN K, MALFAIT, ANNE-MARIE · 2022 to 2025
$11.9MQuantitavie and Computational Biology Graduate ProgramT32HG003284 · NHGRI · PRINCETON UNIVERSITY · PI Joshua Michael Akey, Stanislav Y. Shvartsman · 2004 to 2026
$9.9MCombining New Molecular and Informatic Strategies to Find Hidden Ways to Treat Brain DiseaseR35NS097404 · NINDS · ROCKEFELLER UNIVERSITY · PI DARNELL, ROBERT B · 2017 to 2024
$9.0MTraining Program in Adult and Pediatric RheumatologyT32AR050942 · NIAMS · STANFORD UNIVERSITY · PI LEWIS, DAVID BRAM, ROBINSON, WILLIAM H · 2005 to 2025
$6.6Mlntegration and Visualization of Diverse Biological DataR01GM071966 · NIGMS · PRINCETON UNIVERSITY · PI TROYANSKAYA, OLGA G · 2005 to 2022
$6.4MPrevention Center U01: Early Targets for Antigen-Specific Tolerance Induction in Preclinical Rheumatoid ArthritisU01AI101981 · NIAID · UNIVERSITY OF COLORADO DENVER · PI HOLERS, VERNON MICHAEL · 2012 to 2021
$6.2MCore 2 - Mucosal Immunobiology Core (MIC)P30AR079369 · NIAMS · UNIVERSITY OF COLORADO DENVER · PI Vernon Michael Holers · 2021 to 2026
$4.7MUltra-Fast Epigenomic Maps for Monitoring AutoimmunityU19AI110491 · NIAID · STANFORD UNIVERSITY · PI UTZ, PAUL JOSEPH · 2014 to 2018
$3.6MNCATS NIH HHS UL1 TR001866NCI NIH HHS F30 CA243480NHGRI NIH HHS T32 HG003284NIAID NIH HHS T32 AI007290NIAID NIH HHS U01 AI101981NIAID NIH HHS U19 AI057229NIAID NIH HHS U19 AI110491NIAMS NIH HHS P30 AR079369NIAMS NIH HHS R01 AR063676NIAMS NIH HHS R01 AR078268NIAMS NIH HHS T32 AR050942NIAMS NIH HHS UC2 AR082186NIGMS NIH HHS R01 GM071966NIGMS NIH HHS T32 GM007198NINDS NIH HHS R35 NS097404
Abstract
Periodontal disease is more common in individuals with rheumatoid arthritis (RA) who have detectable anti-citrullinated protein antibodies (ACPAs), implicating oral mucosal inflammation in RA pathogenesis. Here, we performed paired analysis of human and bacterial transcriptomics in longitudinal blood samples from RA patients. We found that patients with RA and periodontal disease experienced repeated oral bacteremias associated with transcriptional signatures of ISG15
Indexed as
Arthritis, RheumatoidPeriodontal DiseasesAminosalicylic AcidsAntibody FormationAutoantibodiesBacteriaEpitopesHumansMouth Mucosaacetyl 4-aminosalicylic acidAminosalicylic AcidsAutoantibodiesEpitopes
Identifiers
What Socratic holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
NCT02051114ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.