ReviewAmerican journal of respiratory and critical care medicine2023
Evolving Management Practices for Early Sepsis-induced Hypoperfusion: A Narrative Review.
Review in American journal of respiratory and critical care medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Clinical efficacy of various resuscitation fluids in the management of sepsis in postoperative surgical and trauma patients: a systematic review and meta--analysis.Wideochirurgia i inne techniki maloinwazyjne = Videosurgery and other miniinvasive techniques · 2024Pooled it
- Complication Rates of Central Venous Catheters: A Systematic Review and Meta-Analysis.JAMA internal medicine · 2024Pooled it
- Comorbidities, Weight-Based Initial Fluid Resuscitation, and Mortality in Patients With Sepsis.JAMA network open · 2026Article
- Artificial Intelligence to Facilitate SEP-1 Measure Compliance and Fluid Management in Sepsis.Journal of clinical medicine · 2026Review
- Group-based trajectory modeling of blood pressure reactivity and mortality in septic patients: a retrospective study of the MIMIC-IV database.BMC infectious diseases · 2026Article
- Effect of norepinephrine initiation timing on mortality in septic shock: a multicenter cohort study.BMC anesthesiology · 2026Observational
- Association between pulse pressure levels and mortality in patients with septic shock: a retrospective cohort study.Frontiers in medicine · 2026Article
- Normal initial lactate level in sepsis patients: is lactate still useful for prognosis prediction?World journal of emergency medicine · 2026Article
- Evaluation of model performance in predicting sepsis after intestinal obstruction surgery: a multicenter retrospective study.Annals of medicine · 2025Article
- Initial fluid resuscitation in septic shock: Reassessing the 30 mL/kg paradigm.Journal of intensive medicine · 2025Article
- Peripheral Vasopressor Use in Early Sepsis-Induced Hypotension.JAMA network open · 2025Article
- Hemoperfusion with Seraph-100 in septic patients removes pathogens and improves clinical outcomes.Scientific reports · 2025Article
- Improving Intestinal Barrier Function in Sepsis by Partially Hydrolysed Guar Gum via the Suppression of the NF-κB/MLCK Pathway.Molecular biotechnology · 2025Article
- Mediating role of blood metabolites in the relationship between immune cell traits and sepsis: a Mendelian randomization and mediation analysis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025Article
- Restrictive fluid resuscitation versus liberal fluid resuscitation in patients with septic shock: comparison of outcomes.American journal of translational research · 2025Article
- Artificial Intelligence to Close the Gap between Pharmacokinetic/Pharmacodynamic Targets and Clinical Outcomes in Critically Ill Patients: A Narrative Review on Beta Lactams.Antibiotics (Basel, Switzerland) · 2024Review
- Association between average mean arterial pressure and 30-day mortality in critically ill patients with sepsis and primary hypertension: a retrospective analysis.Scientific reports · 2024Article
- Hospital-Onset Sepsis Warrants Expanded Investigation and Consideration as a Unique Clinical Entity.Chest · 2024Review
- The hospital frailty risk score effectively predicts adverse outcomes in patients with atrial fibrillation in the intensive care unit.Research square · 2024Article
- Understanding How Clinicians Personalize Fluid and Vasopressor Decisions in Early Sepsis Management.JAMA network open · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 6 countries.
Funding
Abstract
Sepsis causes significant morbidity and mortality worldwide. Resuscitation is a cornerstone of management. This review covers five areas of evolving practice in the management of early sepsis-induced hypoperfusion: fluid resuscitation volume, timing of vasopressor initiation, resuscitation targets, route of vasopressor administration, and use of invasive blood pressure monitoring. For each topic, we review the seminal evidence, discuss the evolution of practice over time, and highlight questions for additional research. Intravenous fluids are a core component of early sepsis resuscitation. However, with growing concerns about the harms of fluid, practice is evolving toward smaller-volume resuscitation, which is often paired with earlier vasopressor initiation. Large trials of fluid-restrictive, vasopressor-early strategies are providing more information about the safety and potential benefit of these approaches. Lowering blood pressure targets is a means to prevent fluid overload and reduce exposure to vasopressors; mean arterial pressure targets of 60-65 mm Hg appear to be safe, at least in older patients. With the trend toward earlier vasopressor initiation, the need for central administration of vasopressors has been questioned, and peripheral vasopressor use is increasing, although it is not universally accepted. Similarly, although guidelines suggest the use of invasive blood pressure monitoring with arterial catheters in patients receiving vasopressors, blood pressure cuffs are less invasive and often sufficient. Overall, the management of early sepsis-induced hypoperfusion is evolving toward fluid-sparing and less-invasive strategies. However, many questions remain, and additional data are needed to further optimize our approach to resuscitation.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.