Evidence mapPaperPMID 36814219Full record

ArticleBMC nephrology2023

Role of foetal kidney size on kidney function in childhood: the born in bradford cohort renal study.

Nida Ziauddeen, Robin F Jeffrey, Dagmar Waiblinger, Simon Ds Fraser, Nisreen A Alwan, Ho M Yuen, Rafaq Azad, Dan Mason, John Wright, Richard Jm Coward and 1 more

Open access · goldAbstract read
In one paragraph

Article in BMC nephrology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Nida ZiauddeenSchool of Primary Care, Population Sciences and Medical Education, Faculty of Medicine, University of Southampton, Southampton, UK. Nida.Ziauddeen@soton.ac.uk.
Robin F JeffreyBradford Institute for Health Research, Bradford Royal Infirmary, Bradford, UK.
Dagmar WaiblingerBradford Institute for Health Research, Bradford Royal Infirmary, Bradford, UK.
Simon Ds FraserSchool of Primary Care, Population Sciences and Medical Education, Faculty of Medicine, University of Southampton, Southampton, UK.
Nisreen A AlwanSchool of Primary Care, Population Sciences and Medical Education, Faculty of Medicine, University of Southampton, Southampton, UK.
Ho M YuenSchool of Primary Care, Population Sciences and Medical Education, Faculty of Medicine, University of Southampton, Southampton, UK.
Rafaq AzadBradford Institute for Health Research, Bradford Royal Infirmary, Bradford, UK.
Dan MasonBradford Institute for Health Research, Bradford Royal Infirmary, Bradford, UK.
John WrightBradford Institute for Health Research, Bradford Royal Infirmary, Bradford, UK.
Richard Jm CowardBristol Renal, Bristol Medical School, University of Bristol, Bristol, UK.
Paul J RoderickSchool of Primary Care, Population Sciences and Medical Education, Faculty of Medicine, University of Southampton, Southampton, UK.
Bradford Royal Infirmary · GBUniversity of Southampton · GBUniversity of Bristol · GB

Funding

British Heart Foundation CS/16/4/32482Medical Research Council G0501901Medical Research Council G0800200Medical Research Council MC_PC_21038Medical Research Council MR/K010492/1Medical Research Council MR/N024397/1Medical Research Council MR/T002263/1Medical Research Council MR/W019582/1Wellcome TrustWellcome Trust WT101597MA
6 · The paper itself

Abstract

backgroundFoetal and early childhood development contributes to the risk of adult non-communicable diseases such as hypertension and cardiovascular disease. We aimed to investigate whether kidney size at birth is associated with markers of kidney function at 7-11 years.

methodsFoetal kidney dimensions were measured using ultrasound scans at 34 weeks gestation and used to derive kidney volume (cm

resultsKidney volume was positively associated in adjusted models with eGFR calculated using Schwartz combined (0.64 ml/min diff per unit increase in volume, 95% CI 0.25 to 1.02), Zappitelli (0.79, 95% CI 0.38 to 1.20) and Filler (2.84, 95% CI 1.40 to 4.28). There was an association with the presence of albuminuria but not with its level, or with other urinary markers or with blood pressure.

conclusionFoetal kidney volume was associated with small increases in eGFR in mid-childhood. Longitudinal follow-up to investigate the relationship between kidney volume and markers of kidney function as children go through puberty is required.

Indexed as

KidneyAlbuminuriaBiomarkersChildCreatinineCystatin CGlomerular Filtration RateHumansInfant, NewbornKidney Function TestsOrgan SizeBiomarkersCreatinineCystatin Cfoetal developmentkidney volume

Identifiers

PMID36814219
PMCPMC9945391
OpenAlexW4321480429

What Socratic holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.