Evidence map›Paper›PMID 36815493›Full record

ArticleBeneficial microbes2023

Probiotic-educated Tregs are more potent than naïve Tregs for immune tolerance in stressed new-born mice.

Y Liu, T K Hoang, E S Park, J Freeborn, B Okeugo, D Q Tran, J M Rhoads

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Beneficial microbes, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Frontiers in immunology · 2026
    Article
  3. ProbioticNutrients · 2024
    Article
  4. Frontiers in cellular and infection microbiology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Y LiuDepartment of Pediatrics, Division of Gastroenterology, McGovern Medical School, University of Texas Health Science Center at Houston, 6431 Fannin Street, MSB 3.137, Houston, TX 77030, USA.
T K HoangDepartment of Pediatrics, Division of Gastroenterology, McGovern Medical School, University of Texas Health Science Center at Houston, 6431 Fannin Street, MSB 3.137, Houston, TX 77030, USA.
E S ParkDepartment of Pediatrics, Division of Gastroenterology, McGovern Medical School, University of Texas Health Science Center at Houston, 6431 Fannin Street, MSB 3.137, Houston, TX 77030, USA.
J FreebornDepartment of Pediatrics, Division of Gastroenterology, McGovern Medical School, University of Texas Health Science Center at Houston, 6431 Fannin Street, MSB 3.137, Houston, TX 77030, USA.
B OkeugoDepartment of Pediatrics, Division of Gastroenterology, McGovern Medical School, University of Texas Health Science Center at Houston, 6431 Fannin Street, MSB 3.137, Houston, TX 77030, USA.
D Q TranDepartment of Pediatrics, Division of Gastroenterology, McGovern Medical School, University of Texas Health Science Center at Houston, 6431 Fannin Street, MSB 3.137, Houston, TX 77030, USA.
J M RhoadsDepartment of Pediatrics, Division of Gastroenterology, McGovern Medical School, University of Texas Health Science Center at Houston, 6431 Fannin Street, MSB 3.137, Houston, TX 77030, USA.
Feminist Archive North · GBThe University of Texas Health Science Center · US

Funding

Tissue Analysis & Molecular Imaging CoreP30DK056338 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI Hashem B El-Serag · 2001 to 2026
$28.3M
Mechanisms of L. reuteri in regulating intestinal inflammationR01AT007083 · NCCIH · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI LIU, YUYING, RHOADS, JON MARC · 2014 to 2018
$1.7M
NCCIH NIH HHS R01 AT007083NIDDK NIH HHS P30 DK056338
6 · The paper itself

Abstract

When new-born mice are subjected to acute maternal separation stress, cow-milk based formula feeding, and brief recurrent hypoxia with cold stress, they develop gut inflammation similar to the phenotype of neonatal necrotizing enterocolitis, characterised by an increase in gut mucosal effector T (Teffs) and reduced Foxp3

Indexed as

ProbioticsT-Lymphocytes, RegulatoryAnimalsCattleFemaleForkhead Transcription FactorsImmune ToleranceIntestinal MucosaMaternal DeprivationMiceForkhead Transcription Factorsadoptive transferimmune toleranceintestinal mucosaLimosilactobacillus reuterimaternal separationstress

Identifiers

PMID36815493
PMCPMC10124588
OpenAlexW4321597506

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.