Evidence map›Paper›PMID 36823181›Full record

ArticleCommunications biology2023

RhoGDIα regulates spermatogenesis through Rac1/cofilin/F-actin signaling.

Haixia Zhu, Zongzhuang Wen, Aizhen Zhang, Dongyue Liu, Hongxiang Wang, Yin Cheng, Xing Yang, Yu Xiao, Jianyuan Li, Daqing Sun and 2 more

Open access · goldAbstract read
In one paragraph

Article in Communications biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. RhoGDI1 regulates cell-cell junctions in polarized epithelial cells.Frontiers in cell and developmental biology · 2024
    Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Haixia Zhu *School of Life Science and Key Laboratory of the Ministry of Education for Experimental Teratology, Shandong University, Jinan, 250100, China.
Zongzhuang Wen *Medical Science and Technology Innovation Center, Shandong First Medical University, Jinan, 250117, China.
Aizhen ZhangSchool of Life Science and Key Laboratory of the Ministry of Education for Experimental Teratology, Shandong University, Jinan, 250100, China.
Dongyue LiuSchool of Life Science and Key Laboratory of the Ministry of Education for Experimental Teratology, Shandong University, Jinan, 250100, China.
Hongxiang WangSchool of Life Science and Key Laboratory of the Ministry of Education for Experimental Teratology, Shandong University, Jinan, 250100, China.
Yin ChengSchool of Life Science and Key Laboratory of the Ministry of Education for Experimental Teratology, Shandong University, Jinan, 250100, China.
Xing YangSchool of Life Science and Key Laboratory of the Ministry of Education for Experimental Teratology, Shandong University, Jinan, 250100, China.
Yu XiaoSchool of Life Science and Key Laboratory of the Ministry of Education for Experimental Teratology, Shandong University, Jinan, 250100, China.
Jianyuan LiKey Laboratory of Male Reproductive Health, National Health and Family Planning Commission, Beijing, 100081, China.
Daqing SunDepartment of Pediatric Surgery, Tianjin Medical University General Hospital, Tianjin, 300052, China. sdqchris2019@tmu.edu.cn.ORCID 0000-0001-9578-8790
Bin WuDepartment of Reproductive Medicine, Central Hospital Affiliated to Shandong First Medical University, Jinan, 250013, China. wb0538@sdu.edu.cn.ORCID 0000-0003-3137-6804
Jiangang GaoSchool of Life Science and Key Laboratory of the Ministry of Education for Experimental Teratology, Shandong University, Jinan, 250100, China. jggao@sdu.edu.cn.ORCID 0000-0001-6619-7107
Shandong University · CNNational Health and Family Planning Commission · CNShandong First Medical University · CNTianjin Medical University General Hospital · CN

Funding

National Natural Science Foundation of China 82070554National Natural Science Foundation of China (National Science Foundation of China) 82271643Natural Science Foundation of Shandong Province (Shandong Provincial Natural Science Foundation) ZR2020MH061
6 · The paper itself

Abstract

Spermatogenesis is an extremely complex process, and any obstruction can cause male infertility. RhoGDIα has been identified as a risk of male sterility. In this study, we generate RhoGDIα knockout mice, and find that the males have severely low fertility. The testes from RhoGDIα

Indexed as

ActinsInfertility, Malerho Guanine Nucleotide Dissociation Inhibitor alphaActin Depolymerizing FactorsAnimalsMaleMiceMice, Knockoutrac1 GTP-Binding ProteinSemenSignal TransductionSpermatogenesisActin Depolymerizing FactorsActinsrac1 GTP-Binding Proteinrho Guanine Nucleotide Dissociation Inhibitor alpha

Identifiers

PMID36823181
PMCPMC9950379
OpenAlexW4321613870

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.