Evidence map›Paper›PMID 36824898›Full record

ArticlebioRxiv : the preprint server for biology2023

Astroglial exosome HepaCAM signaling and ApoE antagonization coordinates early postnatal cortical pyramidal neuronal axon growth and dendritic spine formation.

Shijie Jin, Xuan Chen, Yang Tian, Rachel Jarvis, Vanessa Promes, Yongjie Yang

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Shijie JinTufts University School of Medicine, Department of Neuroscience, Boston, MA, 02111.
Xuan ChenTufts University School of Medicine, Department of Neuroscience, Boston, MA, 02111.
Yang TianTufts University School of Medicine, Department of Neuroscience, Boston, MA, 02111.
Rachel JarvisTufts University School of Medicine, Department of Neuroscience, Boston, MA, 02111.
Vanessa PromesTufts University School of Medicine, Department of Neuroscience, Boston, MA, 02111.
Yongjie YangTufts University School of Medicine, Department of Neuroscience, Boston, MA, 02111.
Tufts University · US

Funding

CNS Exosomes-Mediated Adaptive Immunity in Alzheimer's Disease (AD)R01AG078728 · NIA · TUFTS UNIVERSITY BOSTON · PI ALEXEI DEGTEREV, Yongjie Yang · 2022 to 2026
$4.4M
Exosome-mediated propagation of disease linked poly-dipeptides in C9orf72-FTD/ALSRF1AG057882 · NIA · THOMAS JEFFERSON UNIVERSITY · PI TROTTI, DAVIDE, YANG, YONGJIE · 2018 to 2018
$3.6M
Neuronal/Glial exosome signaling and beta-amyloid propagation in Alzheimer's Disease (AD)RF1AG059610 · NIA · TUFTS UNIVERSITY BOSTON · PI TESCO, GIUSEPPINA, YANG, YONGJIE · 2018 to 2018
$2.7M
Exosomal miRNA in neuron to astroglial communication in the CNSR01NS118747 · NINDS · TUFTS UNIVERSITY BOSTON · PI YANG, YONGJIE · 2020 to 2024
$2.2M
Dysfunctional Astroglial Exosome to (motor) Neuron Axon Signaling in ALSR01NS125490 · NINDS · TUFTS UNIVERSITY BOSTON · PI Yongjie Yang · 2022 to 2026
$2.1M
NIA NIH HHS R01 AG078728NIA NIH HHS RF1 AG057882NIA NIH HHS RF1 AG059610NINDS NIH HHS R01 NS118747NINDS NIH HHS R01 NS125490
6 · The paper itself

Abstract

Developing astroglia play important roles in regulating synaptogenesis through secreted and contact signals. Whether they regulate postnatal axon growth is unknown. By selectively isolating exosomes using size-exclusion chromatography (SEC) and employing cell-type specific exosome reporter mice, our current results define a secreted astroglial exosome pathway that can spread long-range

Identifiers

PMID36824898
PMCPMC9948960
OpenAlexW4320922916

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.