Evidence map›Paper›PMID 36826038›Full record

ArticleCurrent issues in molecular biology2023

Synthesis, Molecular Docking, and Dynamic Simulation Targeting Main Protease (Mpro) of New, Thiazole Clubbed Pyridine Scaffolds as Potential COVID-19 Inhibitors.

Adel Alghamdi, Amr S Abouzied, Abdulwahab Alamri, Sirajudheen Anwar, Mukhtar Ansari, Ibrahim Khadra, Yasser H Zaki, Sobhi M Gomha

Open access · goldAbstract read
In one paragraph

Article in Current issues in molecular biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
14.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 75 citations in OpenAlex.

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  10. Molecular Pharmacology at the Crossroads of Precision Medicine.Current issues in molecular biology · 2025
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  19. Biological Activities and Phytochemical Screening ofInternational journal of molecular sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 3 countries.

Adel AlghamdiPharmaceutical Chemistry Department, Faculty of Clinical Pharmacy, Al Baha University, Al Baha P.O. Box 1988, Saudi Arabia.ORCID 0000-0002-8063-0090
Amr S AbouziedDepartment of Pharmaceutical Chemistry, College of Pharmacy, University of Hail, Hail 81442, Saudi Arabia.ORCID 0000-0002-9202-3909
Abdulwahab AlamriDepartment of Pharmacology and Toxicology, College of Pharmacy, University of Hail, Hail 81442, Saudi Arabia.ORCID 0000-0001-8852-7517
Sirajudheen AnwarDepartment of Pharmacology and Toxicology, College of Pharmacy, University of Hail, Hail 81442, Saudi Arabia.ORCID 0000-0002-0926-2790
Mukhtar AnsariDepartment of Clinical Pharmacy, College of Pharmacy, University of Hail, Hail 81442, Saudi Arabia.ORCID 0000-0002-5247-6356
Ibrahim KhadraStrathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral Street, Glasgow G4 0RE, UK.ORCID 0000-0002-9846-1520
Yasser H ZakiDepartment of Chemistry, Faculty of Science, Beni-Suef University, Beni-Suef 62514, Egypt.ORCID 0000-0002-3502-0445
Sobhi M GomhaDepartment of Chemistry, Faculty of Science, Islamic University of Madinah, Madinah 42351, Saudi Arabia.ORCID 0000-0002-7739-2837
University of Ha'il · SAAl Baha University · SABeni-Suef University · EGCairo University · EGUniversity of Strathclyde · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Many biological activities of pyridine and thiazole derivatives have been reported, including antiviral activity and, more recently, as COVID-19 inhibitors. Thus, in this paper, we designed, synthesized, and characterized a novel series of

Indexed as

acetyl pyridinesCOVID-19hydrazonoyl chloridesmolecular dockingschiff basesthiazoles

Identifiers

PMID36826038
PMCPMC9955078
OpenAlexW4319594632

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.