Evidence map›Paper›PMID 36827119›Full record

ArticleMarine drugs2023

Multiple Effects of Echinochrome A on Selected Ion Channels Implicated in Skin Physiology.

Sung Eun Kim, Elina Da Sol Chung, Elena A Vasileva, Natalia P Mishchenko, Sergey A Fedoreyev, Valentin A Stonik, Hyoung Kyu Kim, Joo Hyun Nam, Sung Joon Kim

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Marine drugs, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.4field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. TRPV3 Ion Channel: From Gene to Pharmacology.International journal of molecular sciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Sung Eun KimDepartment of Physiology, and Department of Biomedical Science, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.ORCID 0000-0002-1902-9095
Elina Da Sol ChungDepartment of Physiology, and Department of Biomedical Science, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.ORCID 0000-0001-8031-9481
Elena A VasilevaG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Science, 690022 Vladivostok, Russia.ORCID 0000-0001-7526-026X
Natalia P MishchenkoG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Science, 690022 Vladivostok, Russia.ORCID 0000-0001-7616-574X
Sergey A FedoreyevG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Science, 690022 Vladivostok, Russia.ORCID 0000-0002-4199-2099
Valentin A StonikG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Science, 690022 Vladivostok, Russia.
Hyoung Kyu KimDepartment of Physiology, College of Medicine, Cardiovascular and Metabolic Disease Center, Smart Marine Therapeutic Center, Department of Health Sciences and Technology, Graduate School, Inje University, Busan 47392, Republic of Korea.ORCID 0000-0002-1791-7865
Joo Hyun NamDepartment of Physiology, Dongguk University College of Medicine, Gyeongju 38066, Republic of Korea.ORCID 0000-0001-8300-6974
Sung Joon KimDepartment of Physiology, and Department of Biomedical Science, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
Seoul National University · KRPacific Institute of Bioorganic Chemistry. GB Elyakova Far Eastern Branch of the Russian Academy of Sciences · RUInje University · KR

Funding

Korea Health Industry Development Institute HP20C0199National Research Foundation of Korea NRF-2018R1A5A2025964
6 · The paper itself

Abstract

Echinochrome A (Ech A), a naphthoquinoid pigment from sea urchins, is known to have anti-inflammatory and analgesic effects that have been suggested to be mediated by antioxidant activity and intracellular signaling modulation. In addition to these mechanisms, the ion channels in keratinocytes, immune cells, and nociceptive neurons may be the target for the pharmacological effects. Here, using the patch clamp technique, we investigated the effects of Ech A on the Ca

Indexed as

NaphthoquinonesFluoxetineHEK293 CellsHumansSkin Physiological Phenomenaechinochrome AFluoxetineNaphthoquinonesnorfluoxetineechinochrome Aion channelorai1skinTREK/TRAAKTRPV1TRPV3

Identifiers

PMID36827119
PMCPMC9963876
OpenAlexW4317821599

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.