Evidence map›Paper›PMID 36829474›Full record

ReviewBiology2023

From Dysbiosis to Neurodegenerative Diseases through Different Communication Pathways: An Overview.

Giorgia Intili, Letizia Paladino, Francesca Rappa, Giusi Alberti, Alice Plicato, Federica Calabrò, Alberto Fucarino, Francesco Cappello, Fabio Bucchieri, Giovanni Tomasello and 2 more

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
8.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Giorgia IntiliBiomedicine, Neuroscience, and Advanced Diagnostics (BIND), University of Palermo, 90127 Palermo, Italy.
Letizia PaladinoBiomedicine, Neuroscience, and Advanced Diagnostics (BIND), University of Palermo, 90127 Palermo, Italy.ORCID 0000-0001-8037-7761
Francesca RappaBiomedicine, Neuroscience, and Advanced Diagnostics (BIND), University of Palermo, 90127 Palermo, Italy.ORCID 0000-0001-6610-5268
Giusi AlbertiBiomedicine, Neuroscience, and Advanced Diagnostics (BIND), University of Palermo, 90127 Palermo, Italy.
Alice PlicatoBiomedicine, Neuroscience, and Advanced Diagnostics (BIND), University of Palermo, 90127 Palermo, Italy.
Federica CalabròBiomedicine, Neuroscience, and Advanced Diagnostics (BIND), University of Palermo, 90127 Palermo, Italy.
Alberto FucarinoBiomedicine, Neuroscience, and Advanced Diagnostics (BIND), University of Palermo, 90127 Palermo, Italy.ORCID 0000-0001-8958-525X
Francesco CappelloBiomedicine, Neuroscience, and Advanced Diagnostics (BIND), University of Palermo, 90127 Palermo, Italy.ORCID 0000-0001-9288-1148
Fabio BucchieriBiomedicine, Neuroscience, and Advanced Diagnostics (BIND), University of Palermo, 90127 Palermo, Italy.
Giovanni TomaselloBiomedicine, Neuroscience, and Advanced Diagnostics (BIND), University of Palermo, 90127 Palermo, Italy.
Francesco CariniBiomedicine, Neuroscience, and Advanced Diagnostics (BIND), University of Palermo, 90127 Palermo, Italy.
Alessandro PitruzzellaBiomedicine, Neuroscience, and Advanced Diagnostics (BIND), University of Palermo, 90127 Palermo, Italy.ORCID 0000-0002-4618-4963
University of Palermo · ITIstituto Euro Mediterraneo di Scienza e Tecnologia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The microbiome research field has rapidly evolved over the last few decades, becoming a major topic of scientific and public interest. The gut microbiota (GM) is the microbial population living in the gut. The GM has many functions, such as maintaining gut homeostasis and host health, providing defense against enteric pathogens, and involvement in immune system development. Several studies have shown that GM is implicated in dysbiosis and is presumed to contribute to neurodegeneration. This review focuses mainly on describing the connection between the intestinal microbiome alterations (dysbiosis) and the onset of neurodegenerative diseases to explore the mechanisms that link the GM to nervous system health, such as the gut-brain axis, as well as the mitochondrial, the adaptive humoral immunity, and the microvesicular pathways. The gut-brain communication depends on a continuous bidirectional flow of molecular signals exchanged through the neural and the systemic circulation. These pathways represent a possible new therapeutic target against neuroinflammation and neurodegeneration. Progress in this context is desperately needed, considering the severity of most neurodegenerative diseases and the current lack of effective treatments.

Indexed as

dysbiosisgut microbiomegut microbiotaneurodegenerative diseases

Identifiers

PMID36829474
PMCPMC9952972
OpenAlexW4318476566

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.