Evidence map›Paper›PMID 36829778›Full record

ReviewAntioxidants (Basel, Switzerland)2023

Epigenetics and Metabolism Reprogramming Interplay into Glioblastoma: Novel Insights on Immunosuppressive Mechanisms.

Filippo Torrisi, Simona D'Aprile, Simona Denaro, Anna Maria Pavone, Cristiana Alberghina, Agata Zappalà, Rosario Giuffrida, Lucia Salvatorelli, Giuseppe Broggi, Gaetano Giuseppe Magro and 3 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Antioxidants (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Filippo TorrisiDepartment of Biomedical and Biotechnological Sciences, Section of Physiology, University of Catania, 95123 Catania, Italy.ORCID 0000-0002-5820-9160
Simona D'AprileDepartment of Biomedical and Biotechnological Sciences, Section of Physiology, University of Catania, 95123 Catania, Italy.
Simona DenaroDepartment of Biomedical and Biotechnological Sciences, Section of Physiology, University of Catania, 95123 Catania, Italy.ORCID 0000-0003-1910-0573
Anna Maria PavoneDepartment of Biomedical and Biotechnological Sciences, Section of Physiology, University of Catania, 95123 Catania, Italy.
Cristiana AlberghinaDepartment of Biomedical and Biotechnological Sciences, Section of Physiology, University of Catania, 95123 Catania, Italy.
Agata ZappalàDepartment of Biomedical and Biotechnological Sciences, Section of Physiology, University of Catania, 95123 Catania, Italy.
Rosario GiuffridaDepartment of Biomedical and Biotechnological Sciences, Section of Physiology, University of Catania, 95123 Catania, Italy.ORCID 0000-0001-7494-3675
Lucia SalvatorelliDepartment of Medical, Surgical Sciences and Advanced Technologies "G.F. Ingrassia", Anatomic Pathology, University of Catania, 95123 Catania, Italy.
Giuseppe BroggiDepartment of Medical, Surgical Sciences and Advanced Technologies "G.F. Ingrassia", Anatomic Pathology, University of Catania, 95123 Catania, Italy.ORCID 0000-0003-2576-6523
Gaetano Giuseppe MagroDepartment of Medical, Surgical Sciences and Advanced Technologies "G.F. Ingrassia", Anatomic Pathology, University of Catania, 95123 Catania, Italy.
Vittorio CalabreseDepartment of Biomedical and Biotechnological Sciences, Section of Biochemistry, University of Catania, 95123 Catania, Italy.ORCID 0000-0002-0478-985X
Nunzio VicarioDepartment of Biomedical and Biotechnological Sciences, Section of Physiology, University of Catania, 95123 Catania, Italy.ORCID 0000-0001-5934-3962
Rosalba ParentiDepartment of Biomedical and Biotechnological Sciences, Section of Physiology, University of Catania, 95123 Catania, Italy.ORCID 0000-0002-1614-4696

Funding

Fondazione Umberto Veronesi Filippo TorrisiPhD program in Biotechnologies, Biometec, University of Catania Simona Denaro, Anna Maria Pavone, Cristiana AlberghinaPON AIM R&I 2014-2020 E66C18001240007
6 · The paper itself

Abstract

The central nervous system represents a complex environment in which glioblastoma adapts skillfully, unleashing a series of mechanisms suitable for its efficient development and diffusion. In particular, changes in gene expression and mutational events that fall within the domain of epigenetics interact complexly with metabolic reprogramming and stress responses enacted in the tumor microenvironment, which in turn fuel genomic instability by providing substrates for DNA modifications. The aim of this review is to analyze this complex interaction that consolidates several conditions that confer a state of immunosuppression and immunoevasion, making glioblastoma capable of escaping attack and elimination by immune cells and therefore invincible against current therapies. The progressive knowledge of the cellular mechanisms that underlie the resistance of the glioblastoma represents, in fact, the only weapon to unmask its weak points to be exploited to plan successful therapeutic strategies.

Indexed as

epigeneticsglioblastomaimmunometabolismimmunosuppressiontumor microenvironment

Identifiers

PMID36829778
PMCPMC9952003

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.