ArticleBiomedicines2023
Vertical Vibration of Mouse Osteoblasts Promotes Cellular Differentiation and Cell Cycle Progression and Induces Aging In Vitro.
Article in Biomedicines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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7 authors at 1 institution in 1 country.
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Abstract
backgroundThis study aimed to investigate the effect of the vibration of osteoblasts on the cell cycle, cell differentiation, and aging. MATERIALS AND
methodsPrimary maxilla osteoblasts harvested from eight-week-old mice were subjected to vibration at 3, 30, and 300 Hz once daily for 30 min; control group, 0 Hz. A cell proliferation assay and Cell-Clock Cell Cycle Assay were performed 24 h after vibration. Osteoblast differentiation assay, aging marker genes, SA-β-Gal activity, and telomere length (qPCR) were assayed two weeks post- vibration once every two days.
resultsCell proliferation increased significantly at 30 and 300 Hz rather than 0 Hz. Several cells were in the late G
conclusionsThe results suggest that providing optimal vibration to osteoblasts promotes cell cycle progression and differentiation and induces cell aging.
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