Evidence map›Paper›PMID 36831019›Full record

ArticleBiomedicines2023

Oncostatin M Receptor Type II Knockout Mitigates Inflammation and Improves Survival from Sepsis in Mice.

Saad Y Salim, Nour AlMalki, Kimberly F Macala, Alyssa Wiedemeyer, Thomas F Mueller, Thomas A Churchill, Stephane L Bourque, Rachel G Khadaroo

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Nonspecific Inhibition of IL6 Family Cytokine Signalling by Soluble gp130.International journal of molecular sciences · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Saad Y SalimDepartment of Surgery, University of Alberta, Edmonton, AB T6G 2B7, Canada.
Nour AlMalkiDepartment of Surgery, University of Alberta, Edmonton, AB T6G 2B7, Canada.
Kimberly F MacalaDepartment of Critical Care Medicine, University of Alberta, Edmonton, AB T6G 2B7, Canada.
Alyssa WiedemeyerDepartment of Anesthesiology and Pain Medicine, University of Alberta, Edmonton, AB T6G 2G3, Canada.
Thomas F MuellerCentre of Excellence for Gastrointestinal Inflammation and Immunity Research (CEGIIR), University of Alberta, Edmonton, AB T6G 2X8, Canada.ORCID 0000-0003-2236-2312
Thomas A ChurchillDepartment of Surgery, University of Alberta, Edmonton, AB T6G 2B7, Canada.
Stephane L BourqueDepartment of Anesthesiology and Pain Medicine, University of Alberta, Edmonton, AB T6G 2G3, Canada.ORCID 0000-0001-6375-7404
Rachel G KhadarooDepartment of Surgery, University of Alberta, Edmonton, AB T6G 2B7, Canada.
University of Alberta · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sepsis remains one of the leading causes of death worldwide. Oncostatin M (OSM), an interleukin (IL)-6 family cytokine, can be found at high levels in septic patients. However, little is known about its role in sepsis. This study aimed to determine if the genetic knockout of OSM receptor (OSMR) type II signaling would improve survival in a murine model of sepsis. Aged (>50 weeks) OSMR type II knockout (KO) mice and wild-type (WT) littermates received an intraperitoneal injection of fecal slurry (FS) or vehicle. The KO mice had better survival 48 h after the injection of FS than the WT mice (

Indexed as

bacterial clearancefecal slurry induced peritonitisinflammationknockout micemacrophage recruitment

Identifiers

PMID36831019
PMCPMC9953488
OpenAlexW4319596695

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.