ReviewBiomedicines2023
Novel Adipokines and Their Role in Bone Metabolism: A Narrative Review.
Review in Biomedicines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03887936 (Testosterone Therapy and Bone Quality in Men With Diabetes and Hypogonadism), which is not on this map. Cited by 42 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Testosterone Therapy and Bone Quality in Men With Diabetes and Hypogonadism
Who cites it
42 citing papers in PubMed, 46 citations in OpenAlex.
- Trial
- Lipid Metabolic Reprogramming in Periodontitis-Associated Alveolar Bone Remodeling: Mechanisms, Signaling Pathways, and Therapeutic Implications.Biomolecules · 2026Review
- Why Do We Lose Bone During Weight Loss: Can It Be Prevented?Current osteoporosis reports · 2026Review
- Article
- Circulating Apelin-13, β-catenin and bone mineral density in postmenopausal women.Endocrine connections · 2026Article
- Association of intra-pancreatic fat deposition with bone marrow adiposity in young obese adults.Quantitative imaging in medicine and surgery · 2026Article
- Type 1 Diabetes Mellitus as a Model of Body Composition Transformation: Pathogenetic Unity of Combined Phenotypes.International journal of molecular sciences · 2026Review
- Inversed impaired osteogenic activity in children with severe obesity due to MC4R deficiency compared to LEP and LEPR deficiency.International journal of obesity (2005) · 2026Article
- Association between weight-to-waist ratio and total bone mineral density in US adults: A cross-sectional study of the National Health and Nutrition Examination Survey 2011-2018.The Journal of international medical research · 2026Article
- The Intimate Relationship between Adipose Tissue, Fertility, and Bone.Journal of frailty, sarcopenia and falls · 2026Review
- Profiling the secretome: maternal obesity impacts redox and adipogenic signaling during neonatal mesenchymal stem cell adipogenesis.Stem cells (Dayton, Ohio) · 2026Article
- Marrow leptin-LEPR signaling rewires mitochondrial oxidative metabolism to confer chemoresistance in acute myeloid leukemia.Cell death & disease · 2026Article
- Bone and muscle crosstalk in steroid-induced osteonecrosis of the femoral head: a four-axis pathophysiological framework.Frontiers in immunology · 2026Review
- Interorgan Communications in Skeletal Pathophysiology: From Molecular Pathways to Multidisciplinary Therapies.Research (Washington, D.C.) · 2026Review
- Residential altitude was not independently associated with osteoporosis among long-term Qinghai-Tibetan Plateau residents.Frontiers in public health · 2026Article
- Perirenal fat and alcohol consumption contribute to marginal bone loss after dental implant surgery in type 2 diabetes.World journal of diabetes · 2025Article
- The association between body fat distribution and osteosarcopenia in older adults: evidence from the PoCOsteo study.Aging clinical and experimental research · 2025Article
- An aptamer specifically targeting mCRP ameliorates experimental arthritis.Journal of orthopaedic translation · 2025Article
- Association of metabolic score for visceral fat (METS-VF) with lumbar spine bone mineral density in US adults.Scientific reports · 2025Article
- Adipocyte-Tumor Interactions in the Bone Marrow Niche: Implications for Metastasis and Therapy.International journal of molecular sciences · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The growing burden of obesity and osteoporosis is a major public health concern. Emerging evidence of the role of adipokines on bone metabolism has led to the discovery of novel adipokines over the last decade. Obesity is recognized as a state of adipose tissue inflammation that adversely affects bone health. Adipokines secreted from white adipose tissue (WAT) and bone marrow adipose tissue (BMAT) exerts endocrine and paracrine effects on the survival and function of osteoblasts and osteoclasts. An increase in marrow fat is implicated in osteoporosis and, hence, it is crucial to understand the complex interplay between adipocytes and bone. The objective of this review is to summarize recent advances in our understanding of the role of different adipokines on bone metabolism.
methodsThis is a comprehensive review of the literature available in PubMED and Cochrane databases, with an emphasis on the last five years using the keywords.
resultsLeptin has shown some positive effects on bone metabolism; in contrast, both adiponectin and chemerin have consistently shown a negative association with BMD. No significant association was found between resistin and BMD. Novel adipokines such as visfatin, LCN-2, Nesfatin-1, RBP-4, apelin, and vaspin have shown bone-protective and osteoanabolic properties that could be translated into therapeutic targets.
conclusionNew evidence suggests the potential role of novel adipokines as biomarkers to predict osteoporosis risk, and as therapeutic targets for the treatment of osteoporosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.