Evidence map›Paper›PMID 36831639›Full record

ArticleCancers2023

Sex- and Female Age-Dependent Differences in Gene Expression in Diffuse Large B-Cell Lymphoma-Possible Estrogen Effects.

Dan Huang, Mattias Berglund, Anastasios Damdimopoulos, Per Antonson, Cecilia Lindskog, Gunilla Enblad, Rose-Marie Amini, Sam Okret

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Genes Co-Expressed withInternational journal of molecular sciences · 2024
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Dan HuangDepartment of Biosciences and Nutrition, Karolinska Institutet, SE-141 83 Huddinge, Sweden.
Mattias BerglundDepartment of Biosciences and Nutrition, Karolinska Institutet, SE-141 83 Huddinge, Sweden.
Anastasios DamdimopoulosBioinformatics and Expression Core Facility, Department of Biosciences and Nutrition, Karolinska Institutet, SE-141 83 Huddinge, Sweden.
Per AntonsonDepartment of Biosciences and Nutrition, Karolinska Institutet, SE-141 83 Huddinge, Sweden.ORCID 0000-0001-9335-9941
Cecilia LindskogDepartment of Immunology, Genetics and Pathology, Uppsala University, SE-751 85 Uppsala, Sweden.
Gunilla EnbladDepartment of Immunology, Genetics and Pathology, Uppsala University, SE-751 85 Uppsala, Sweden.
Rose-Marie AminiDepartment of Immunology, Genetics and Pathology, Uppsala University, SE-751 85 Uppsala, Sweden.
Sam OkretDepartment of Biosciences and Nutrition, Karolinska Institutet, SE-141 83 Huddinge, Sweden.ORCID 0000-0003-0822-1847
Karolinska Institutet · SEUppsala University · SE

Funding

Barncancerfonden PR2019-0019Swedish Cancer Society 20 1024 PjF
6 · The paper itself

Abstract

For most lymphomas, including diffuse large B-cell lymphoma (DLBCL), the male incidence is higher, and the prognosis is worse compared to females. The reasons are unclear; however, epidemiological and experimental data suggest that estrogens are involved. With this in mind, we analyzed gene expression data from a publicly available cohort (EGAD00001003600) of 746 DLBCL samples based on RNA sequencing. We found 1293 genes to be differentially expressed between males and females (adj.

Indexed as

diffuse large B-cell lymphomaestrogengene expressionMUC5BNR4Apre- vs. postmenopausRNA sequencingsex difference

Identifiers

PMID36831639
PMCPMC9954534
OpenAlexW4321377268

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.