Circulating Nitric Oxide and Metabolic Syndrome in Arab Children and Adolescents: A Case-Control Study.

Osama E Amer, Shaun Sabico, Malak N K Khattak, Nasser M Al-Daghri

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Article in Children (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

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4 · The record

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5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Osama E AmerBiochemistry Department, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.ORCID 0000-0002-8657-0682

Shaun SabicoBiochemistry Department, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.ORCID 0000-0002-5248-2350

Malak N K KhattakBiochemistry Department, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.

Nasser M Al-DaghriBiochemistry Department, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.ORCID 0000-0001-5472-1725

King Saud University · SA

Funding

Deputyship for Research and Innovation, Ministry of Education in Saudi Arabia IFKSURG-2-27

6 · The paper itself

Abstract

backgroundMetabolic syndrome (MetS) represents a cluster of known cardiometabolic risk factors, which elevates the risk of type 2 diabetes mellitus (T2DM), atherosclerotic cardiovascular disease (CVD) and chronic kidney disease (CKD) in adults and, only recently, even in children and adolescents. Circulating nitric oxide (NOx) has been observed to influence MetS risk factors in adults, but this has been scarcely investigated in children. The aim of the present study was to determine whether circulating NOx levels correlate with known components of MetS in Arab children and adolescents.

methodsAnthropometrics, serum NOx, lipid profile and fasting glucose levels were measured in 740 Saudi Arabs aged 10-17 years (68.8% girls). The presence of MetS was screened using the criteria of de Ferranti et al. Results: Overall, serum NOx levels were significantly higher in MetS participants compared to non-MetS (25.7 µmol/L (10.1-46.7) versus 11.9 µmol/L (5.5-22.9),

conclusionsMetS and most of its components were significantly associated with circulating NOx levels in Arab adolescents and may be a promising diagnostic biomarker for MetS.

Indexed as

cardiovascular diseasesdiabetes mellitusdyslipidemiaSaudisexual dimorphism

Identifiers

PMID36832339

DOI10.3390/children10020210

PMCPMC9954847

OpenAlexW4318053662

What Socratic holds

Textmetadata

LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.