Evidence map›Paper›PMID 36832540›Full record

ArticleChildren (Basel, Switzerland)2023

Neuroactive Amino Acid Profile in Autism Spectrum Disorder: Results from a Clinical Sample.

Martina Randazzo, Adriana Prato, MariaAnna Messina, Concetta Meli, Antonino Casabona, Renata Rizzo, Rita Barone

Open access · goldAbstract read
In one paragraph

Article in Children (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 22 citations in OpenAlex.

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  15. Metabolomic changes in children with autism.World journal of clinical pediatrics · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Martina RandazzoChild Neurology and Psychiatry, Department of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy.ORCID 0000-0003-3756-3934
Adriana PratoChild Neurology and Psychiatry, Department of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy.ORCID 0000-0003-1083-7915
MariaAnna MessinaReferral Centre for Inherited Metabolic Disorders, Department of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy.ORCID 0000-0002-8652-4248
Concetta MeliReferral Centre for Inherited Metabolic Disorders, Department of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy.
Antonino CasabonaDepartment of Biomedical and Biotechnological Sciences, Section of Physiology, University of Catania, 95123 Catania, Italy.ORCID 0000-0003-0180-4695
Renata RizzoChild Neurology and Psychiatry, Department of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy.ORCID 0000-0002-3997-1328
Rita BaroneChild Neurology and Psychiatry, Department of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy.ORCID 0000-0001-6302-2686
University of Catania · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biological bases of autism spectrum disorder (ASD) include both genetic and epigenetic causes. Patients with ASD show anomalies in the profile of certain plasma amino acids, including neuroactive amino acids. Monitoring plasma amino acids may be relevant for patient care and interventions. We evaluated the plasma amino acid profile in samples extracted from dry blood spots by electrospray ionization-tandem mass spectrometry. Fourteen amino acids and eleven amino acid ratios were examined in patients with ASD and intellectual disability (ID), and neurotypical control subjects (TD). The amino acid profile in the ASD group showed reduced levels of ornithine (

Indexed as

amino acidsautism spectrum disorderdried blood spotsESI-MS/MSintellectual disabilitymetabolism

Identifiers

PMID36832540
PMCPMC9955282
OpenAlexW4321457127

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.