Evidence map›Paper›PMID 36833456›Full record

ArticleGenes2023

miR-33a Inhibits the Differentiation of Bovine Preadipocytes through the IRS2-Akt Pathway.

Wenzhen Zhang, Sayed Haidar Abbas Raza, Bingzhi Li, Bing Sun, Sihu Wang, Sameer D Pant, Nouf S Al-Abbas, Nehad A Shaer, Linsen Zan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Wenzhen ZhangCollege of Animal Science and Technology, Northwest A&F University, Yangling 712100, China.
Sayed Haidar Abbas RazaCollege of Animal Science and Technology, Northwest A&F University, Yangling 712100, China.ORCID 0000-0002-0961-1911
Bingzhi LiCollege of Animal Science and Technology, Northwest A&F University, Yangling 712100, China.
Bing SunCollege of Animal Science and Technology, Northwest A&F University, Yangling 712100, China.
Sihu WangCollege of Animal Science and Technology, Northwest A&F University, Yangling 712100, China.
Sameer D PantGulbali Institute, Charles Sturt University, Boorooma Street, Wagga Wagga, NSW 2678, Australia.
Nouf S Al-AbbasDepartment of Biology, Jamoum University College, Umm Al-Qura University, Makkah 21955, Saudi Arabia.ORCID 0000-0002-2981-2622
Nehad A ShaerDepartment of Chemistry, Al Lieth University College, Umm Al-Qura University, Makkah 21955, Saudi Arabia.
Linsen ZanCollege of Animal Science and Technology, Northwest A&F University, Yangling 712100, China.
Northwest A&F University · CNUmm al-Qura University · SACharles Sturt University · AUNational Beef Cattle Industrial Technology System · CNSouth China Agricultural University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Several microRNAs (miRNAs) are known to participate in adipogenesis. However, their role in this process, especially in the differentiation of bovine preadipocytes, remains to be elucidated. This study was intended to clarify the effect of microRNA-33a (miR-33a) on the differentiation of bovine preadipocytes by cell culture, real-time fluorescent quantitative PCR (qPCR), Oil Red staining, BODIPY staining, and Western blotting. The results indicate that overexpression of miR-33a significantly inhibited lipid droplet accumulation and decreased the mRNA and protein expression of adipocyte differentiation marker genes such as peroxisome proliferator-activated receptor gamma (PPARγ), sterol regulatory element-binding protein 1 (SREBP1), and fatty acid-binding protein 4 (FABP4). In contrast, the interference expression of miR-33a promoted lipid droplet accumulation and increased the expression of marker genes. Additionally, miR-33a directly targeted insulin receptor substrate 2 (

Indexed as

MicroRNAsProto-Oncogene Proteins c-aktAdipogenesisAnimalsCattleCell DifferentiationInsulin Receptor Substrate ProteinsInsulin Receptor Substrate ProteinsMicroRNAsProto-Oncogene Proteins c-aktAkt pathwaybovineIRS2miR-33apreadipocyte differentiation

Identifiers

PMID36833456
PMCPMC9957011
OpenAlexW4321372597

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.