Evidence map›Paper›PMID 36834530›Full record

ArticleInternational journal of molecular sciences2023

Monoglyceride Lipase Deficiency Is Associated with Altered Thrombogenesis in Mice.

Madeleine Goeritzer, Katharina B Kuentzel, Sarah Beck, Melanie Korbelius, Silvia Rainer, Ivan Bradić, Dagmar Kolb, Marion Mussbacher, Waltraud C Schrottmaier, Alice Assinger and 8 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 99% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 3 institutions in 2 countries.

Madeleine GoeritzerGottfried Schatz Research Center, Molecular Biology and Biochemistry, Medical University of Graz, 8010 Graz, Austria.
Katharina B KuentzelGottfried Schatz Research Center, Molecular Biology and Biochemistry, Medical University of Graz, 8010 Graz, Austria.ORCID 0000-0002-1445-5466
Sarah BeckInstitute of Vascular Biology and Thrombosis Research, Center for Physiology and Pharmacology, Medical University of Vienna, 1190 Vienna, Austria.ORCID 0000-0002-7102-8241
Melanie KorbeliusGottfried Schatz Research Center, Molecular Biology and Biochemistry, Medical University of Graz, 8010 Graz, Austria.ORCID 0000-0002-7609-9436
Silvia RainerGottfried Schatz Research Center, Molecular Biology and Biochemistry, Medical University of Graz, 8010 Graz, Austria.
Ivan BradićGottfried Schatz Research Center, Molecular Biology and Biochemistry, Medical University of Graz, 8010 Graz, Austria.
Dagmar KolbCore Facility Ultrastructural Analysis, Medical University of Graz, 8010 Graz, Austria.
Marion MussbacherDepartment of Pharmacology and Toxicology, University of Graz, 8010 Graz, Austria.ORCID 0000-0001-5346-6785
Waltraud C SchrottmaierCore Facility Ultrastructural Analysis, Medical University of Graz, 8010 Graz, Austria.ORCID 0000-0003-0550-4120
Alice AssingerCore Facility Ultrastructural Analysis, Medical University of Graz, 8010 Graz, Austria.ORCID 0000-0002-5670-5910
Axel SchlagenhaufDepartment of General Pediatrics and Adolescent Medicine, Medical University of Graz, 8010 Graz, Austria.
René RostGottfried Schatz Research Center, Molecular Biology and Biochemistry, Medical University of Graz, 8010 Graz, Austria.ORCID 0000-0002-5393-0370
Benjamin GottschalkGottfried Schatz Research Center, Molecular Biology and Biochemistry, Medical University of Graz, 8010 Graz, Austria.
Thomas O EichmannInstitute of Molecular Biosciences, University of Graz, 8010 Graz, Austria.
Thomas ZülligInstitute of Molecular Biosciences, University of Graz, 8010 Graz, Austria.ORCID 0000-0002-8483-0962
Wolfgang F GraierGottfried Schatz Research Center, Molecular Biology and Biochemistry, Medical University of Graz, 8010 Graz, Austria.ORCID 0000-0003-1871-3298
Nemanja VujićGottfried Schatz Research Center, Molecular Biology and Biochemistry, Medical University of Graz, 8010 Graz, Austria.ORCID 0000-0003-2977-7799
Dagmar KratkyGottfried Schatz Research Center, Molecular Biology and Biochemistry, Medical University of Graz, 8010 Graz, Austria.ORCID 0000-0003-1357-7573
Medical University of Graz · ATUniversity of Graz · ATUniversity of Würzburg · DE

Funding

Austrian Science Fund FWF P 30882Austrian Science Fund FWF P 32400Austrian Science Fund FWF W 1226
6 · The paper itself

Abstract

Monoglyceride lipase (MGL) hydrolyzes monoacylglycerols (MG) to glycerol and one fatty acid. Among the various MG species, MGL also degrades 2-arachidonoylglycerol, the most abundant endocannabinoid and potent activator of the cannabinoid receptors 1 and 2. We investigated the consequences of MGL deficiency on platelet function using systemic (Mgl

Indexed as

Monoacylglycerol LipasesMonoglyceridesAnimalsEndocannabinoidsLipolysisMiceMice, Inbred C57BLMice, KnockoutEndocannabinoidsMgll protein, mouseMonoacylglycerol LipasesMonoglyceridesin vitro and in vivo thrombus formationMGLplatelet activationplatelet aggregationplatelets

Identifiers

PMID36834530
PMCPMC9958834
OpenAlexW4319318186

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.