Evidence mapPaperPMID 36834662Full record

ArticleInternational journal of molecular sciences2023

Insights into Insulin Resistance and Calcification in the Myocardium in Type 2 Diabetes: A Coronary Artery Analysis.

Queralt Martín-Saladich, Rafael Simó, Santiago Aguadé-Bruix, Olga Simó-Servat, Carolina Aparicio-Gómez, Cristina Hernández, Clara Ramirez-Serra, María Nazarena Pizzi, Albert Roque, Miguel A González Ballester and 1 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Queralt Martín-SaladichMedical Molecular Imaging Research Group, Nuclear Medicine, Radiology and Cardiology Departments, Vall d'Hebron Research Institute (VHIR), Vall d'Hebron University Hospital, Autonomous University Barcelona, 08035 Barcelona, Spain.ORCID 0000-0003-4798-1558
Rafael SimóDiabetes and Metabolism Research Group, VHIR, Department of Endocrinology, Vall d'Hebron University Hospital, Autonomous University Barcelona, 08035 Barcelona, Spain.ORCID 0000-0003-0475-3096
Santiago Aguadé-BruixMedical Molecular Imaging Research Group, Nuclear Medicine, Radiology and Cardiology Departments, Vall d'Hebron Research Institute (VHIR), Vall d'Hebron University Hospital, Autonomous University Barcelona, 08035 Barcelona, Spain.ORCID 0000-0001-8617-6274
Olga Simó-ServatDiabetes and Metabolism Research Group, VHIR, Department of Endocrinology, Vall d'Hebron University Hospital, Autonomous University Barcelona, 08035 Barcelona, Spain.
Carolina Aparicio-GómezMedical Molecular Imaging Research Group, Nuclear Medicine, Radiology and Cardiology Departments, Vall d'Hebron Research Institute (VHIR), Vall d'Hebron University Hospital, Autonomous University Barcelona, 08035 Barcelona, Spain.
Cristina HernándezDiabetes and Metabolism Research Group, VHIR, Department of Endocrinology, Vall d'Hebron University Hospital, Autonomous University Barcelona, 08035 Barcelona, Spain.
Clara Ramirez-SerraClinical Biochemistry Research Group, Vall d'Hebron Research Institute (VHIR), Biochemical Core Facilities, Vall d'Hebron University Hospital, Autonomous University Barcelona, 08035 Barcelona, Spain.
María Nazarena PizziDepartment of Medicine, Autonomous University of Barcelona, 08193 Barcelona, Spain.
Albert RoqueMedical Molecular Imaging Research Group, Nuclear Medicine, Radiology and Cardiology Departments, Vall d'Hebron Research Institute (VHIR), Vall d'Hebron University Hospital, Autonomous University Barcelona, 08035 Barcelona, Spain.
Miguel A González BallesterBCN Medtech, Department of Information and Communication Technologies, Pompeu Fabra University, 08018 Barcelona, Spain.ORCID 0000-0002-9227-6826
José Raul HeranceMedical Molecular Imaging Research Group, Nuclear Medicine, Radiology and Cardiology Departments, Vall d'Hebron Research Institute (VHIR), Vall d'Hebron University Hospital, Autonomous University Barcelona, 08035 Barcelona, Spain.ORCID 0000-0001-7178-3290
Instituto de Salud Carlos III · ESVall d'Hebron Institut de Recerca · ESUniversitat Autònoma de Barcelona · ESInstitució Catalana de Recerca i Estudis Avançats · ESUniversitat Pompeu Fabra · ES

Funding

Instituto de Salud Carlos III FI21/00304Instituto de Salud Carlos III PI20/01588
6 · The paper itself

Abstract

Type 2 diabetes (T2D) is responsible for high incidence of cardiovascular (CV) complications leading to heart failure. Coronary artery region-specific metabolic and structural assessment could provide deeper insight into the extent of the disease and help prevent adverse cardiac events. Therefore, in this study, we aimed at investigating such myocardial dynamics for the first time in insulin-sensitive (mIS) and insulin-resistant (mIR) T2D patients. We targeted global and region-specific variations using insulin sensitivity (IS) and coronary artery calcifications (CACs) as CV risk factor in T2D patients. IS was computed using myocardial segmentation approaches at both baseline and after an hyperglycemic-insulinemic clamp (HEC) on [

Indexed as

CalcinosisCoronary Artery DiseaseDiabetes Mellitus, Type 2Heart DiseasesInsulin ResistancePlaque, AtheroscleroticVascular CalcificationCoronary VesselsHumansInsulinMyocardiumRadiopharmaceuticalsInsulinRadiopharmaceuticals[18F]FDG-PET imagingcalcificationcardiovascular riskcomputed tomographycoronary arteryinsulin sensibilitymetabolic diseasemyocardiumtype 2 diabetes

Identifiers

PMID36834662
PMCPMC9959651
OpenAlexW4319441939

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.