Evidence map›Paper›PMID 36834691›Full record

ArticleInternational journal of molecular sciences2023

Loss of S1P Lyase Expression in Human Podocytes Causes a Reduction in Nephrin Expression That Involves PKCδ Activation.

Faik Imeri, Bisera Stepanovska Tanturovska, Roxana Manaila, Hermann Pavenstädt, Josef Pfeilschifter, Andrea Huwiler

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
  3. Sphingolipids and Chronic Kidney Disease.Journal of clinical medicine · 2024
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Faik ImeriInstitute of Pharmacology, Inselspital, INO-F, University of Bern, CH-3010 Bern, Switzerland.
Bisera Stepanovska TanturovskaInstitute of Pharmacology, Inselspital, INO-F, University of Bern, CH-3010 Bern, Switzerland.
Roxana ManailaInstitute of Pharmacology, Inselspital, INO-F, University of Bern, CH-3010 Bern, Switzerland.
Hermann PavenstädtMedizinische Klinik D, University Hospital Münster, D-48149 Münster, Germany.
Josef PfeilschifterPharmazentrum Frankfurt/ZAFES, University Hospital, Goethe University Frankfurt am Main, Theodor-Stern Kai 7, D-60590 Frankfurt am Main, Germany.
Andrea HuwilerInstitute of Pharmacology, Inselspital, INO-F, University of Bern, CH-3010 Bern, Switzerland.ORCID 0000-0003-1615-5691
University of Bern · CHGoethe University Frankfurt · DEUniversity Hospital Münster · DE

Funding

Deutsche Forschungsgemeinschaft SFB 1039Hochschulstiftung der Universität Bern 20/2020Swiss National Science Foundation 310030_175561/1
6 · The paper itself

Abstract

Sphingosine 1-phosphate (S1P) lyase (SPL,

Indexed as

Nephrotic SyndromePodocytesAldehyde-LyasesAnimalsHumansInterleukin-6Membrane ProteinsMiceProtein Kinase C-deltaRNA, MessengerAldehyde-LyasesInterleukin-6Membrane ProteinsnephrinProtein Kinase C-deltaRNA, MessengerSGPL1 protein, humanglomerular diseasenephrinnephrotic syndromepodocytesprotein kinase Cdeltasphingosine 1-phosphatesphingosine 1-phosphate lyaseWilms tumor suppressor gene 1

Identifiers

PMID36834691
PMCPMC9965238
OpenAlexW4319600874

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.