Evidence map›Paper›PMID 36835032›Full record

ArticleInternational journal of molecular sciences2023

Sublingual Microcirculation Specificity of Sickle Cell Patients: Morphology of the Microvascular Bed, Blood Rheology, and Local Hemodynamics.

Sachi Sant, Etienne Gouraud, Camille Boisson, Elie Nader, Mounika Goparaju, Giovanna Cannas, Alexandra Gauthier, Philippe Joly, Céline Renoux, Salima Merazga and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Sachi SantDepartment of Mechanical Engineering, University of Ottawa, Ottawa, ON K1N 6N5, Canada.
Etienne GouraudLaboratoire Interuniversitaire de Biologie de la Motricité (LIBM) EA7424, Team «Vascular Biology and Red Blood Cell», Université Claude Bernard Lyon 1, 69008 Lyon, France.ORCID 0000-0003-1377-5318
Camille BoissonLaboratoire Interuniversitaire de Biologie de la Motricité (LIBM) EA7424, Team «Vascular Biology and Red Blood Cell», Université Claude Bernard Lyon 1, 69008 Lyon, France.ORCID 0000-0002-4208-8376
Elie NaderLaboratoire Interuniversitaire de Biologie de la Motricité (LIBM) EA7424, Team «Vascular Biology and Red Blood Cell», Université Claude Bernard Lyon 1, 69008 Lyon, France.
Mounika GoparajuDepartment of Mechanical Engineering, University of Ottawa, Ottawa, ON K1N 6N5, Canada.
Giovanna CannasService de Médecine Interne, Hôpital Edouard Herriot, Hospices Civils de Lyon, 69008 Lyon, France.
Alexandra GauthierInstitut Hématologique Oncologique Pédiatrique (IHOPe), Hospices Civils de Lyon, 69008 Lyon, France.
Philippe JolyLaboratoire Interuniversitaire de Biologie de la Motricité (LIBM) EA7424, Team «Vascular Biology and Red Blood Cell», Université Claude Bernard Lyon 1, 69008 Lyon, France.ORCID 0000-0002-2351-9441
Céline RenouxLaboratoire Interuniversitaire de Biologie de la Motricité (LIBM) EA7424, Team «Vascular Biology and Red Blood Cell», Université Claude Bernard Lyon 1, 69008 Lyon, France.
Salima MerazgaService de Médecine Interne, Hôpital Edouard Herriot, Hospices Civils de Lyon, 69008 Lyon, France.
Christophe HautierLaboratoire Interuniversitaire de Biologie de la Motricité (LIBM) EA7424, Team «Vascular Biology and Red Blood Cell», Université Claude Bernard Lyon 1, 69008 Lyon, France.
Philippe ConnesLaboratoire Interuniversitaire de Biologie de la Motricité (LIBM) EA7424, Team «Vascular Biology and Red Blood Cell», Université Claude Bernard Lyon 1, 69008 Lyon, France.ORCID 0000-0002-9232-0268
Marianne FenechDepartment of Mechanical Engineering, University of Ottawa, Ottawa, ON K1N 6N5, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patients with sickle cell disease (SCD) have poorly deformable red blood cells (RBC) that may impede blood flow into microcirculation. Very few studies have been able to directly visualize microcirculation in humans with SCD. Sublingual video microscopy was performed in eight healthy (HbAA genotype) and four sickle cell individuals (HbSS genotype). Their hematocrit, blood viscosity, red blood cell deformability, and aggregation were individually determined through blood sample collections. Their microcirculation morphology (vessel density and diameter) and microcirculation hemodynamics (local velocity, local viscosity, and local red blood cell deformability) were investigated. The De Backer score was higher (15.9 mm

Indexed as

Anemia, Sickle CellMouth FloorErythrocytesHemodynamicsHemoglobin, SickleHumansMicrocirculationRheologyHemoglobin, Sicklemicrocirculationred blood cell deformabilitysickle cell diseasesidestream dark field imaging

Identifiers

PMID36835032
PMCPMC9967909

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.