Evidence map›Paper›PMID 36835187›Full record

ArticleInternational journal of molecular sciences2023

Plasma IAPP-Autoantibody Levels in Alzheimer's Disease Patients Are Affected by

Dovilė Pocevičiūtė, Bodil Roth, Nina Schultz, Cristina Nuñez-Diaz, Shorena Janelidze, The Netherlands Brain Bank, Anders Olofsson, Oskar Hansson, Malin Wennström

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Dovilė PocevičiūtėCognitive Disorder Research Unit, Department of Clinical Sciences Malmö, Lund University, 214 28 Malmö, Sweden.
Bodil RothDepartment of Internal Medicine, Lund University, Skåne University Hospital, 214 28 Malmö, Sweden.
Nina SchultzClinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, 223 62 Lund, Sweden.ORCID 0000-0001-8202-6455
Cristina Nuñez-DiazCognitive Disorder Research Unit, Department of Clinical Sciences Malmö, Lund University, 214 28 Malmö, Sweden.
Shorena JanelidzeClinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, 223 62 Lund, Sweden.
The Netherlands Brain BankNetherlands Institute for Neuroscience, 1105 BA Amsterdam, The Netherlands.
Anders OlofssonDepartment of Medical Biochemistry and Biophysics, Umeå University, 901 87 Umeå, Sweden.ORCID 0000-0002-8743-8720
Oskar HanssonClinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, 223 62 Lund, Sweden.
Malin WennströmCognitive Disorder Research Unit, Department of Clinical Sciences Malmö, Lund University, 214 28 Malmö, Sweden.
Lund University · SENetherlands Institute for Neuroscience · NL

Funding

Åhlensfonden Not providedÅhlén-Stiftelsen 223006Alzheimerfonden Not providedBrain Foundation FO2022-0039Dementia Foundation 2021Greta and Johan Kockska foundation 2021Kempe foundation Not providedKnut and Alice Wallenberg Foundation 2017-0383Norrländska hjärtfonden Not providedOlle Engkvists foundation 194-643Parkinson Foundation of Sweden 1412/22Regionalt Forskningsstöd 2022-1259Skåne University Hospital Foundation 2020-O000028Söderbergs stiftelse M55/22Swedish Alzheimer foundation AF-980907Swedish Brain Foundation FO2021-0293Swedish federal government under the ALF agreement 2022-Projekt0080Swedish Research Council 2018-02564Swedish Research Council 2022-00775the Cure Alzheimer's fund Not providedthe Konung Gustaf V:s and Drottning Victorias Frimurarestiftelse Not providedthe Strategic Research Area MultiPark (Multidisciplinary Research in Parkinson's disease) at Lund University Not provided
6 · The paper itself

Abstract

Pancreas-derived islet amyloid polypeptide (IAPP) crosses the blood-brain barrier and co-deposits with amyloid beta (Aβ) in brains of type 2 diabetes (T2D) and Alzheimer's disease (AD) patients. Depositions might be related to the circulating IAPP levels, but it warrants further investigation. Autoantibodies recognizing toxic IAPP oligomers (IAPP

Indexed as

Alzheimer DiseaseApolipoprotein E4Islet Amyloid PolypeptideAmyloid beta-PeptidesDiabetes Mellitus, Type 2HumansImmunoglobulin AAmyloid beta-PeptidesApolipoprotein E4Immunoglobulin AIslet Amyloid PolypeptideADamylinamyloid betaAPOE4autoantibodiescognitionIgAIgGIgMT2D

Identifiers

PMID36835187
PMCPMC9960837
OpenAlexW4320731450

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.