Evidence map›Paper›PMID 36835202›Full record

ArticleInternational journal of molecular sciences2023

Co-Expression Analysis of Airway Epithelial Transcriptome in Asthma Patients with Eosinophilic vs. Non-Eosinophilic Airway Infiltration.

Pawel Kozlik-Siwiec, Sylwia Buregwa-Czuma, Izabela Zawlik, Sylwia Dziedzina, Aleksander Myszka, Joanna Zuk-Kuwik, Andzelika Siwiec-Kozlik, Jacek Zarychta, Krzysztof Okon, Lech Zareba and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Pawel Kozlik-SiwiecDepartment of Internal Medicine, Jagiellonian University Medical College, 31-066 Krakow, Poland.
Sylwia Buregwa-CzumaCollege of Natural Sciences, Institute of Computer Science, University of Rzeszow, Pigonia 1, 35-310 Rzeszow, Poland.
Izabela ZawlikCentre for Innovative Research in Medical and Natural Sciences, Institute of Medical Sciences, Medical College, University of Rzeszow, Kopisto 2a, 35-959 Rzeszow, Poland.
Sylwia DziedzinaDepartment of Internal Medicine, Jagiellonian University Medical College, 31-066 Krakow, Poland.
Aleksander MyszkaInstitute of Medical Sciences, Medical College, University of Rzeszow, Kopisto 2a, 35-959 Rzeszow, Poland.
Joanna Zuk-KuwikHaematology Clinical Department, University Hospital, 31-501 Krakow, Poland.
Andzelika Siwiec-KozlikRheumatology and Immunology Clinical Department, University Hospital, 31-688 Krakow, Poland.ORCID 0000-0003-2258-0248
Jacek ZarychtaDepartment of Internal Medicine, Jagiellonian University Medical College, 31-066 Krakow, Poland.
Krzysztof OkonDepartment of Pathology, Jagiellonian University Medical College, 33-332 Krakow, Poland.ORCID 0000-0002-1921-5007
Lech ZarebaCollege of Natural Sciences, Institute of Computer Science, University of Rzeszow, Pigonia 1, 35-310 Rzeszow, Poland.ORCID 0000-0002-2221-614X
Jerzy SojaDepartment of Internal Medicine, Jagiellonian University Medical College, 31-066 Krakow, Poland.
Bogdan JakielaDepartment of Internal Medicine, Jagiellonian University Medical College, 31-066 Krakow, Poland.ORCID 0000-0003-0444-981X
Michał KepskiCollege of Natural Sciences, Institute of Computer Science, University of Rzeszow, Pigonia 1, 35-310 Rzeszow, Poland.
Jan G BazanCollege of Natural Sciences, Institute of Computer Science, University of Rzeszow, Pigonia 1, 35-310 Rzeszow, Poland.
Stanislawa Bazan-SochaDepartment of Internal Medicine, Jagiellonian University Medical College, 31-066 Krakow, Poland.ORCID 0000-0001-9634-0963

Funding

National Science Centre of the Polish Ministry of Science DEC-2013/09/B/NZ5/00758
6 · The paper itself

Abstract

Asthma heterogeneity complicates the search for targeted treatment against airway inflammation and remodeling. We sought to investigate relations between eosinophilic inflammation, a phenotypic feature frequent in severe asthma, bronchial epithelial transcriptome, and functional and structural measures of airway remodeling. We compared epithelial gene expression, spirometry, airway cross-sectional geometry (computed tomography), reticular basement membrane thickness (histology), and blood and bronchoalveolar lavage (BAL) cytokines of

Indexed as

AsthmaPulmonary EosinophiliaRespiratory MucosaAirway RemodelingCalmodulin-Binding ProteinsGPI-Linked ProteinsHumansInflammationSOXB2 Transcription FactorsTranscriptomeCalmodulin-Binding ProteinsGPI-Linked ProteinsRECK protein, humanSOX14 protein, humanSOXB2 Transcription FactorsSTRN4 protein, humanairway remodelingasthmabasement membranebronchialdifferential co-expressiondifferential expressioneosinophilicepithelialtranscriptome

Identifiers

PMID36835202
PMCPMC9959255

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.