Evidence map›Paper›PMID 36835312›Full record

ArticleInternational journal of molecular sciences2023

Inguinal Fat Compensates Whole Body Metabolic Functionality in Partially Lipodystrophic Mice with Reduced PPARγ Expression.

Cherng-Shyang Chang, Shang-Shiuan Yu, Li-Chun Ho, Shu-Hsin Chao, Ting-Yu Chou, Ai-Ning Shao, Ling-Zhen Kao, Chia-Yu Chang, Yu-Hsin Chen, Ming-Shan Wu and 3 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Cherng-Shyang ChangInstitute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan.
Shang-Shiuan YuInstitute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan.
Li-Chun HoSchool of Medicine, College of Medicine, I-Shou University, Kaohsiung 824, Taiwan.ORCID 0000-0002-0796-8853
Shu-Hsin ChaoInstitute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan.
Ting-Yu ChouInstitute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan.
Ai-Ning ShaoInstitute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan.
Ling-Zhen KaoInstitute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan.
Chia-Yu ChangInstitute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan.
Yu-Hsin ChenInstitute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan.
Ming-Shan WuInstitute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan.
Pei-Jane TsaiInstitute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan.ORCID 0000-0002-3370-9839
Nobuyo MaedaDepartment of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599, USA.
Yau-Sheng TsaiInstitute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan.ORCID 0000-0002-5560-2661
National Cheng Kung University · TWE-Da Hospital · TWNational Cheng Kung University Hospital · TWUniversity of North Carolina at Chapel Hill · US

Funding

MODELS FOR STUDYING THE GENETICS OF HYPERTENSIONR01HL049277 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MAEDA, NOBUYO · 1992 to 2025
$17.5M
APOLIPOROTEIN GENES AND ATHEROGENESISR01HL042630 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MAEDA, NOBUYO · 1989 to 2017
$4.9M
APOLIPOPROTEIN GENES AND ATHEROGENESIS IN ANIMALSR37HL042630 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MAEDA, NOBUYO · 1998 to 2007
$3.4M
NHLBI NIH HHS R01 HL042630NHLBI NIH HHS R01 HL049277NHLBI NIH HHS R37 HL042630
6 · The paper itself

Abstract

Peroxisome proliferator-activated receptor γ (PPARγ) gene mutations in humans and mice lead to whole-body insulin resistance and partial lipodystrophy. It is unclear whether preserved fat depots in partial lipodystrophy are beneficial for whole-body metabolic homeostasis. We analyzed the insulin response and expression of metabolic genes in the preserved fat depots of

Indexed as

Insulin ResistanceLipodystrophy, Familial PartialPPAR gammaAnimalsHumansInsulinLipodystrophyMiceMutationInsulinPPAR gammaadipose tissue flexibilityfat depotinguinal fat-dependence indexinsulin sensitivitypartial lipodystrophyPPARγ

Identifiers

PMID36835312
PMCPMC9966317
OpenAlexW4320918902

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.