Evidence map›Paper›PMID 36835366›Full record

ArticleInternational journal of molecular sciences2023

5-FU-miR-15a Inhibits Activation of Pancreatic Stellate Cells by Reducing YAP1 and BCL-2 Levels In Vitro.

Vanessa M Diaz Almanzar, Kunal Shah, Joseph F LaComb, Aisharja Mojumdar, Hetvi R Patel, Jacky Cheung, Meiyi Tang, Jingfang Ju, Agnieszka B Bialkowska

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Vanessa M Diaz AlmanzarDepartment of Medicine, Renaissance School of Medicine at Stony Brook University, Stony Brook, NY 11794, USA.ORCID 0000-0002-1811-2364
Kunal ShahDepartment of Medicine, Renaissance School of Medicine at Stony Brook University, Stony Brook, NY 11794, USA.
Joseph F LaCombDepartment of Medicine, Renaissance School of Medicine at Stony Brook University, Stony Brook, NY 11794, USA.ORCID 0000-0002-2981-1072
Aisharja MojumdarDepartment of Medicine, Renaissance School of Medicine at Stony Brook University, Stony Brook, NY 11794, USA.
Hetvi R PatelDepartment of Medicine, Renaissance School of Medicine at Stony Brook University, Stony Brook, NY 11794, USA.
Jacky CheungDepartment of Medicine, Renaissance School of Medicine at Stony Brook University, Stony Brook, NY 11794, USA.
Meiyi TangDepartment of Medicine, Renaissance School of Medicine at Stony Brook University, Stony Brook, NY 11794, USA.
Jingfang JuDepartment of Pathology, Renaissance School of Medicine at Stony Brook University, Stony Brook, NY 11794, USA.
Agnieszka B BialkowskaDepartment of Medicine, Renaissance School of Medicine at Stony Brook University, Stony Brook, NY 11794, USA.ORCID 0000-0003-2127-7714
Stony Brook School · US

Funding

Mechanisms of injury-induced pancreatic neoplasiaR01DK124342 · NIDDK · STATE UNIVERSITY NEW YORK STONY BROOK · PI BIALKOWSKA, AGNIESZKA BEATA · 2020 to 2023
$1.4M
NIDDK NIH HHS R01 DK124342NIH HHS DK124342
6 · The paper itself

Abstract

Chronic pancreatitis is characterized by chronic inflammation and fibrosis, processes heightened by activated pancreatic stellate cells (PSCs). Recent publications have demonstrated that miR-15a, which targets

Indexed as

FluorouracilMicroRNAsPancreatic Stellate CellsPancreatitis, ChronicAnimalsCell ProliferationFibrosisMiceProto-Oncogene Proteins c-bcl-2YAP-Signaling ProteinsFluorouracilMicroRNAsMirn15a microRNA, mouseProto-Oncogene Proteins c-bcl-2Yap1 protein, mouseYAP-Signaling Proteinschronic pancreatitismicroRNApancreatic stellate cells

Identifiers

PMID36835366
PMCPMC9961454
OpenAlexW4321097042

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.