Evidence map›Paper›PMID 36835522›Full record

ArticleInternational journal of molecular sciences2023

Amin Ravaei, Lia Pulsatelli, Elisa Assirelli, Jacopo Ciaffi, Riccardo Meliconi, Carlo Salvarani, Marcello Govoni, Michele Rubini

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. International journal of molecular medicine · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Amin RavaeiMedical Genetics Laboratory, Department of Neuroscience and Rehabilitation, University of Ferrara, 44121 Ferrara, Italy.ORCID 0000-0002-9050-1030
Lia PulsatelliLaboratory of Immunorheumatology and Tissue Regeneration, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, Italy.
Elisa AssirelliMedicine and Rheumatology Unit, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, Italy.ORCID 0000-0001-5678-6506
Jacopo CiaffiMedicine and Rheumatology Unit, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, Italy.ORCID 0000-0002-9446-7351
Riccardo MeliconiMedicine and Rheumatology Unit, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, Italy.
Carlo SalvaraniDivision of Rheumatology, Azienda USL-IRCCS di Reggio Emilia, 42122 Reggio Emilia, Italy.
Marcello GovoniSection of Hematology and Rheumatology, Department of Medical Sciences, University of Ferrara, 44121 Ferrara, Italy.ORCID 0000-0003-0499-5773
Michele RubiniMedical Genetics Laboratory, Department of Neuroscience and Rehabilitation, University of Ferrara, 44121 Ferrara, Italy.ORCID 0000-0003-1448-9516
Istituto Ortopedico Rizzoli · ITUniversity of Ferrara · ITUniversity of Modena and Reggio Emilia · IT

Funding

Emilia/Romagna Region PRUA1GR-2013-00000203Italian Ministry of Health 5‰ funds 2020University of Ferrara FAR-2021
6 · The paper itself

Abstract

Rheumatoid arthritis (RA) is an inflammatory autoimmune disease with a prevalence of 1%. Currently, RA treatment aims to achieve low disease activity or remission. Failure to achieve this goal causes disease progression with a poor prognosis. When treatment with first-line drugs fails, treatment with tumor necrosis factor-α (TNF-α) inhibitors may be prescribed to which many patients do not respond adequately, making the identification of response markers urgent. This study investigated the association of two RA-related genetic polymorphisms, c.665C>T (historically referred to as C677T) and c.1298A>C, in the

Indexed as

Antirheumatic AgentsArthritis, RheumatoidMethylenetetrahydrofolate Reductase (NADPH2)Tumor Necrosis Factor InhibitorsGene FrequencyHumansPolymorphism, Single NucleotideAntirheumatic AgentsMethylenetetrahydrofolate Reductase (NADPH2)MTHFR protein, humanTumor Necrosis Factor Inhibitorsbiomarkersgenetic associationMTHFRpersonalized medicinepharmacogeneticsrheumatoid arthritisTNF-α inhibitors

Identifiers

PMID36835522
PMCPMC9962934
OpenAlexW4321374404

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.