Evidence map›Paper›PMID 36835636›Full record

ArticleInternational journal of molecular sciences2023

Polydopamine Incorporation Enhances Cell Differentiation and Antibacterial Properties of 3D-Printed Guanosine-Borate Hydrogels for Functional Tissue Regeneration.

Maria Merino-Gómez, Javier Gil, Roman A Perez, Maria Godoy-Gallardo

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Maria Merino-GómezBioengineering Institute of Technology (BIT), International University of Catalonia (UIC), Carrer de Josep Trueta, Sant Cugat del Vallès, 08195 Barcelona, Spain.
Javier GilBioengineering Institute of Technology (BIT), International University of Catalonia (UIC), Carrer de Josep Trueta, Sant Cugat del Vallès, 08195 Barcelona, Spain.ORCID 0000-0002-6824-1412
Roman A PerezBioengineering Institute of Technology (BIT), International University of Catalonia (UIC), Carrer de Josep Trueta, Sant Cugat del Vallès, 08195 Barcelona, Spain.ORCID 0000-0002-0823-2303
Maria Godoy-GallardoBioengineering Institute of Technology (BIT), International University of Catalonia (UIC), Carrer de Josep Trueta, Sant Cugat del Vallès, 08195 Barcelona, Spain.ORCID 0000-0002-7232-3998
Universitat Internacional de Catalunya · ES

Funding

Government of Catalonia 2018 BP 00155Government of Catalonia 2021 SGR 00565Government of Spain RTI2018-096088-J-100Government of Spain RYC2018-025977-I
6 · The paper itself

Abstract

Tissue engineering focuses on the development of materials as biosubstitutes that can be used to regenerate, repair, or replace damaged tissues. Alongside this, 3D printing has emerged as a promising technique for producing implants tailored to specific defects, which in turn increased the demand for new inks and bioinks. Especially supramolecular hydrogels based on nucleosides such as guanosine have gained increasing attention due to their biocompatibility, good mechanical characteristics, tunable and reversible properties, and intrinsic self-healing capabilities. However, most existing formulations exhibit insufficient stability, biological activity, or printability. To address these limitations, we incorporated polydopamine (PDA) into guanosine-borate (GB) hydrogels and developed a PGB hydrogel with maximal PDA incorporation and good thixotropic and printability qualities. The resulting PGB hydrogels exhibited a well-defined nanofibrillar network, and we found that PDA incorporation increased the hydrogel's osteogenic activity while having no negative effect on mammalian cell survival or migration. In contrast, antimicrobial activity was observed against the Gram-positive bacteria

Indexed as

BoratesHydrogelsAnimalsAnti-Bacterial AgentsCell DifferentiationGuanosineIndolesMammalsPolymersPrinting, Three-DimensionalTissue EngineeringTissue ScaffoldsAnti-Bacterial AgentsBoratesGuanosineHydrogelsIndolespolydopaminePolymers3D printingantibacterial activityguanosine and derivativesnucleoside-based hydrogelspolydopamine

Identifiers

PMID36835636
PMCPMC9964593
OpenAlexW4321372634

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.