Evidence map›Paper›PMID 36835646›Full record

ReviewInternational journal of molecular sciences2023

View from the Biological Property: Insight into the Functional Diversity and Complexity of the Gut Mucus.

Chengwei He, Han Gao, Shuzi Xin, Rongxuan Hua, Xueran Guo, Yimin Han, Hongwei Shang, Jingdong Xu

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Chengwei HeDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China.ORCID 0000-0002-7215-053X
Han GaoDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China.
Shuzi XinDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China.
Rongxuan HuaDepartment of Clinical Medicine, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China.
Xueran GuoDepartment of Clinical Medicine, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China.
Yimin HanDepartment of Oral Medicine, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China.
Hongwei ShangExperimental Center for Morphological Research Platform, Capital Medical University, Beijing 100069, China.
Jingdong XuDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China.ORCID 0000-0003-4546-563X
Capital Medical University · CN

Funding

National Natural Science Foundation of China No.82174056 and No. 81673671
6 · The paper itself

Abstract

Due to mucin's important protective effect on epithelial tissue, it has garnered extensive attention. The role played by mucus in the digestive tract is undeniable. On the one hand, mucus forms "biofilm" structures that insulate harmful substances from direct contact with epithelial cells. On the other hand, a variety of immune molecules in mucus play a crucial role in the immune regulation of the digestive tract. Due to the enormous number of microorganisms in the gut, the biological properties of mucus and its protective actions are more complicated. Numerous pieces of research have hinted that the aberrant expression of intestinal mucus is closely related to impaired intestinal function. Therefore, this purposeful review aims to provide the highlights of the biological characteristics and functional categorization of mucus synthesis and secretion. In addition, we highlight a variety of the regulatory factors for mucus. Most importantly, we also summarize some of the changes and possible molecular mechanisms of mucus during certain disease processes. All these are beneficial to clinical practice, diagnosis, and treatment and can provide some potential theoretical bases. Admittedly, there are still some deficiencies or contradictory results in the current research on mucus, but none of this diminishes the importance of mucus in protective impacts.

Indexed as

Intestinal MucosaMucusBiofilmsEpithelial CellsEpitheliumbarrier functionbiological characteristicshealth and illnessmucinmucusphenotypic switch

Identifiers

PMID36835646
PMCPMC9960128
OpenAlexW4321459781

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.