Evidence map›Paper›PMID 36836853›Full record

ArticleLife (Basel, Switzerland)2023

The Joint Link of the rs1051730 and rs1902341 Polymorphisms and Cigarette Smoking to Peripheral Artery Disease and Atherosclerotic Lesions of Different Arterial Beds.

Sergey Zhabin, Victor Lazarenko, Iuliia Azarova, Elena Klyosova, Marina Bykanova, Svetlana Chernousova, Daniil Bashkatov, Ekaterina Gneeva, Anna Polonikova, Mikhail Churnosov and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. A Narrative Review of the Correlation Between Comorbidity and Acute Exacerbation of COPD Patients.International journal of chronic obstructive pulmonary disease · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Sergey ZhabinDepartment of Surgical Diseases №1, Kursk State Medical University, 3 Karl Marx Street, Kursk 305041, Russia.
Victor LazarenkoDepartment of Surgical Diseases of Institute of Continuing Education, Kursk State Medical University, 3 Karl Marx Street, Kursk 305041, Russia.
Iuliia AzarovaDepartment of Biological Chemistry, Kursk State Medical University, 3 Karl Marx Street, Kursk 305041, Russia.
Elena KlyosovaLaboratory of Biochemical Genetics and Metabolomics, Research Institute for Genetic and Molecular Epidemiology, Kursk State Medical University, 18 Yamskaya St., Kursk 305041, Russia.ORCID 0000-0002-1543-9230
Marina BykanovaLaboratory of Genomic Research, Research Institute for Genetic and Molecular Epidemiology, Kursk State Medical University, 18 Yamskaya St., Kursk 305041, Russia.
Svetlana ChernousovaDepartment of Surgical Diseases №1, Kursk State Medical University, 3 Karl Marx Street, Kursk 305041, Russia.
Daniil BashkatovDepartment of Surgical Diseases №1, Kursk State Medical University, 3 Karl Marx Street, Kursk 305041, Russia.ORCID 0000-0002-7404-4933
Ekaterina GneevaDepartment of Surgical Diseases №1, Kursk State Medical University, 3 Karl Marx Street, Kursk 305041, Russia.
Anna PolonikovaDepartment of Biology, Medical Genetics and Ecology, Kursk State Medical University, 3 Karl Marx Street, Kursk 305041, Russia.
Mikhail ChurnosovDepartment of Medical Biological Disciplines, Belgorod State University, 85 Pobedy Street, Belgorod 308015, Russia.ORCID 0000-0003-1254-6134
Maria SolodilovaDepartment of Biology, Medical Genetics and Ecology, Kursk State Medical University, 3 Karl Marx Street, Kursk 305041, Russia.
Alexey PolonikovDepartment of Biology, Medical Genetics and Ecology, Kursk State Medical University, 3 Karl Marx Street, Kursk 305041, Russia.ORCID 0000-0001-6280-247X
Kursk State Medical University · RUBelgorod National Research University · RU

Funding

Kursk State Medical University No
6 · The paper itself

Abstract

Genome-wide association studies (GWAS) have discovered numerous single nucleotide polymorphisms (SNP) contributing to peripheral artery disease (PAD), but their joint effects with risk factors like cigarette smoking (CS) on disease susceptibility have not been systematically investigated. The present study looked into whether CS mediates the effects of GWAS loci on the development of PAD and atherosclerotic lesions in different arterial beds. DNA samples from 1263 unrelated individuals of Slavic origin including 620 PAD patients and 643 healthy subjects were genotyped by the MassArray-4 system for rs1051730, rs10134584, rs1902341, rs10129758 which are known as PAD-associated GWAS loci. The rs1051730 polymorphism was strongly associated with an increased risk of PAD (

Indexed as

cigarette smokinggeneticsgenome-wide association study (GWAS)peripheral artery diseasesingle nucleotide polymorphism

Identifiers

PMID36836853
PMCPMC9961460
OpenAlexW4320496878

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.