Evidence map›Paper›PMID 36837786›Full record

ArticleMetabolites2023

Neonatal Orally Administered Zingerone Attenuates Alcohol-Induced Fatty Liver Disease in Experimental Rat Models.

Bernice Asiedu, Busisani Wiseman Lembede, Monica Gomes, Abe Kasonga, Pilani Nkomozepi, Trevor Tapiwa Nyakudya, Eliton Chivandi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Metabolites, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Bernice AsieduSchool of Physiology, Faculty of Health Sciences, University of the Witwaterstrand, 7 York Street, Parktown, Johannesburg 2193, South Africa.ORCID 0000-0001-6407-7566
Busisani Wiseman LembedeSchool of Physiology, Faculty of Health Sciences, University of the Witwaterstrand, 7 York Street, Parktown, Johannesburg 2193, South Africa.ORCID 0000-0003-0291-4511
Monica GomesSchool of Physiology, Faculty of Health Sciences, University of the Witwaterstrand, 7 York Street, Parktown, Johannesburg 2193, South Africa.ORCID 0000-0002-4599-6601
Abe KasongaDepartment of Physiology, School of Medicine, Faculty of Health Sciences, University of Pretoria, Private Bag X323, Gezina, Pretoria 0031, South Africa.ORCID 0000-0001-7379-6044
Pilani NkomozepiDepartment of Human Anatomy and Physiology, Faculty of Health Sciences, University of Johannesburg, Corner Beit and Siemert Street, Doornfontein, Johannesburg 2094, South Africa.
Trevor Tapiwa NyakudyaDepartment of Physiology, School of Medicine, Faculty of Health Sciences, University of Pretoria, Private Bag X323, Gezina, Pretoria 0031, South Africa.ORCID 0000-0003-1872-9257
Eliton ChivandiSchool of Physiology, Faculty of Health Sciences, University of the Witwaterstrand, 7 York Street, Parktown, Johannesburg 2193, South Africa.ORCID 0000-0003-0386-4245
University of the Witwatersrand · ZAUniversity of Pretoria · ZAUniversity of Johannesburg · ZA

Funding

Faculty of health sciences research committee and the school of physiology of the University of Witwaterstrand 001 254 8521101 5121105 000000 0000000000 5254National Research Foundation TTK170415227205
6 · The paper itself

Abstract

Alcohol intake at different developmental stages can lead to the development of alcohol-induced fatty liver disease (AFLD). Zingerone (ZO) possess hepato-protective properties; thus, when administered neonatally, it could render protection against AFLD. This study aimed to evaluate the potential long-term protective effect of ZO against the development of AFLD. One hundred and twenty-three 10-day-old Sprague-Dawley rat pups (60 males; 63 females) were randomly assigned to four groups and orally administered the following treatment regimens daily during the pre-weaning period from postnatal day (PND) 12-21: group 1-nutritive milk (NM), group 2-NM +1 g/kg ethanol (Eth), group 3-NM + 40 mg/kg ZO, group 4-NM + Eth +ZO. From PND 46-100, each group from the neonatal stage was divided into two; subgroup I had tap water and subgroup II had ethanol solution as drinking fluid, respectively, for eight weeks. Mean daily ethanol intake, which ranged from 10 to 14.5 g/kg body mass/day, resulted in significant CYP2E1 elevation (

Indexed as

alcohol-induced fatty liver diseasemacrosteatosisperoxisome proliferator activator receptor-alpha (PPAR-α)sterol regulatory element binding protein 1c (SREBP1c)zingerone

Identifiers

PMID36837786
PMCPMC9966972
OpenAlexW4317906789

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.