ArticleMetabolites2023
Serum Uric Acid Predicts All-Cause and Cardiovascular Mortality Independently of Hypertriglyceridemia in Cardiometabolic Patients without Established CV Disease: A Sub-Analysis of the URic acid Right for heArt Health (URRAH) Study.
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Article in Metabolites, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
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Who cites it
11 citing papers in PubMed, 22 citations in OpenAlex.
- Predictive value of TG/HDL-C and GFR-adjusted uric acid levels on cardiovascular mortality: the URRAH study.Lipids in health and disease · 2025Article
- The role of insulin resistance in the relationship between uric acid and the severity of coronary artery disease: evidence from real-world data.Frontiers in nutrition · 2025Article
- The Role of Hyperuricemia in Cardiac Diseases: Evidence, Controversies, and Therapeutic Strategies.Biomolecules · 2024Review
- Serum Uric Acid, Hypertriglyceridemia, and Carotid Plaques: A Sub-Analysis of the URic Acid Right for Heart Health (URRAH) Study.Metabolites · 2024Article
- Progress of uric acid in cardiovascular disease.Cardiovascular endocrinology & metabolism · 2024Review
- Expert consensus for the diagnosis and treatment of patients with hyperuricemia and high cardiovascular risk: 2023 update.Cardiology journal · 2024Article
- The Results of the URRAH (Uric Acid Right for Heart Health) Project: A Focus on Hyperuricemia in Relation to Cardiovascular and Kidney Disease and its Role in Metabolic Dysregulation.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2023Review
- Association between serum uric acid and triglyceride-glucose index in children and adolescents with short stature.Scientific reports · 2023Article
- Purine Metabolism Dysfunctions: Experimental Methods of Detection and Diagnostic Potential.International journal of molecular sciences · 2023Review
- Untangling the relationship between bempedoic acid and gout: results from a systematic literature review.Frontiers in cardiovascular medicine · 2023Review
- Correlation Analysis and Diagnostic Value of Serum Homocysteine, Cystatin C and Uric Acid Levels with the Severity of Coronary Artery Stenosis in Patients with Coronary Heart Disease.International journal of general medicine · 2023Article
Corrections and comments
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Authors and funding
47 authors at 20 institutions in 2 countries.
Alessandro MengozziDepartment of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy.ORCID 0000-0003-2834-9725
Nicola Riccardo PuglieseDepartment of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy.ORCID 0000-0002-5473-227X
Giovambattista DesideriDepartment of Life, Health and Environmental Sciences, University of L'Aquila, 67100 L'Aquila, Italy.ORCID 0000-0002-0145-1271
Stefano MasiDepartment of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy.ORCID 0000-0002-7591-3686
Fabio AngeliDepartment of Medicine and Surgery, University of Insubria, 21100 Varese, Italy.ORCID 0000-0003-4925-7985
Carlo Maria BarbagalloBiomedical Department of Internal Medicine and Specialistics, University of Palermo, 90100 Palermo, Italy.ORCID 0000-0002-4114-038X
Michele BombelliClinica Medica, Department of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy.
Federica CappelliDepartment of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy.
Edoardo CasigliaStudium Patavinum, Department of Medicine, University of Padua, 35100 Padua, Italy.ORCID 0000-0002-0003-3289
Rosario CianciDepartment of Translational and Precision Medicine, Sapienza University of Rome, 00185 Rome, Italy.
Michele CiccarelliDepartment of Advanced Biomedical Sciences, "Federico II" University of Naples, 80133 Naples, Italy.ORCID 0000-0003-2379-1960
Arrigo F G CiceroDepartment Hypertension and Cardiovascular Disease Research Center, Medical and Surgical Sciences Department, Alma Mater Studiorum University of Bologna, 40126 Bologna, Italy.ORCID 0000-0002-4367-3884
Massimo CirilloDepartment of Public Health, "Federico II" University of Naples, 80133 Naples, Italy.ORCID 0000-0002-6409-3504
Pietro CirilloNephrology, Dialysis and Transplantation Unit, Department of Emergency and Organ Transplantation, "Aldo Moro" University of Bari, 70122 Bari, Italy.
Raffaella Dell'OroClinica Medica, Department of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy.
Lanfranco D'EliaDepartment of Clinical Medicine and Surgery, "Federico II" University of Naples, 80133 Naples, Italy.ORCID 0000-0002-1782-0211
Claudio FerriDepartment of Life, Health and Environmental Sciences, University of L'Aquila, 67100 L'Aquila, Italy.
Ferruccio GallettiDepartment of Clinical Medicine and Surgery, "Federico II" University of Naples, 80133 Naples, Italy.
Loreto GesualdoNephrology, Dialysis and Transplantation Unit, Department of Emergency and Organ Transplantation, "Aldo Moro" University of Bari, 70122 Bari, Italy.ORCID 0000-0002-4861-0911
Cristina GiannattasioCardiology IV, "A.De Gasperi's" Department, Niguarda Ca' Granda Hospital, 20162 Milan, Italy.
Guido GrassiClinica Medica, Department of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy.
Guido IaccarinoDepartment of Advanced Biomedical Sciences, "Federico II" University of Naples, 80133 Naples, Italy.
Luciano LippaItalian Society of General Medicine (SIMG), 67051 Avezzano, Italy.ORCID 0000-0003-1249-3861
Francesca MallamaciCNR-IFC, Clinical Epidemiology of Renal Diseases and Hypertension, Reggio Cal Unit, 89124 Reggio Calabria, Italy.
Alessandro MalobertiCardiology IV, "A.De Gasperi's" Department, Niguarda Ca' Granda Hospital, 20162 Milan, Italy.ORCID 0000-0002-2612-6264
Maria MasulliDepartment of Clinical Medicine and Surgery, "Federico II" University of Naples, 80133 Naples, Italy.
Alberto MazzaDepartment of Internal Medicine, Santa Maria Della Misericordia General Hospital, AULSS 5 Polesana, 45100 Rovigo, Italy.
Maria Lorenza MuiesanDepartment of Clinical and Experimental Sciences, University of Brescia, 25121 Brescia, Italy.ORCID 0000-0002-4007-9441
Pietro NazzaroDepartment of Precision and Regenerative Medicine and Jonic Area (DiMePRe-J), Neurosciences and Sense Organs, University of Bari Medical School, 70122 Bari, Italy.
Paolo PalatiniStudium Patavinum, Department of Medicine, University of Padua, 35100 Padua, Italy.ORCID 0000-0001-5402-4946
Gianfranco ParatiS. Luca Hospital, Istituto Auxologico Italiano & University of Milan-Bicocca, 20126 Milan, Italy.ORCID 0000-0001-9402-7439
Roberto PontremoliDepartment of Internal Medicine, University of Genoa; IRCSS Ospedale Policlinico San Martino, 16132 Genova, Italy.ORCID 0000-0003-1238-872X
Fosca Quarti-TrevanoClinica Medica, Department of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy.ORCID 0000-0002-7357-0931
Marcello RattazziDepartment of Medicine-DIMED, University of Padova, Medicina Interna 1°, Ca' Foncello University Hospital, 31100 Treviso, Italy.
Gianpaolo ReboldiDepartment of Medical and Surgical Science, University of Perugia, 06100 Perugia, Italy.ORCID 0000-0002-9877-0702
Giulia RivasiDepartment of Geriatric and Intensive Care Medicine, Careggi Hospital, University of Florence, 50121 Florence, Italy.ORCID 0000-0002-2736-2242
Elisa RussoDepartment of Internal Medicine, University of Genoa; IRCSS Ospedale Policlinico San Martino, 16132 Genova, Italy.ORCID 0000-0003-1279-3178
Massimo SalvettiDepartment of Clinical and Experimental Sciences, University of Brescia, 25121 Brescia, Italy.ORCID 0000-0001-8101-1374
Valerie TikhonoffDepartment of Medicine, University of Padua, 35100 Padua, Italy.ORCID 0000-0001-7846-0101
Giuliano TocciDepartment of Clinical and Molecular Medicine, University of Rome Sapienza, 00185 Rome, Italy.ORCID 0000-0002-0635-4921
Andrea UngarDepartment of Geriatric and Intensive Care Medicine, Careggi Hospital, University of Florence, 50121 Florence, Italy.
Paolo VerdecchiaHospital S. Maria della Misericordia, 06100 Perugia, Italy.
Francesca ViazziDepartment of Internal Medicine, University of Genoa; IRCSS Ospedale Policlinico San Martino, 16132 Genova, Italy.ORCID 0000-0003-4219-7043
Massimo VolpeDepartment of Clinical and Molecular Medicine, University of Rome Sapienza, 00185 Rome, Italy.
Claudio BorghiDepartment Hypertension and Cardiovascular Disease Research Center, Medical and Surgical Sciences Department, Alma Mater Studiorum University of Bologna, 40126 Bologna, Italy.ORCID 0000-0001-8039-8781
Agostino VirdisDepartment of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy.ORCID 0000-0002-6994-0223
Working Group on Uric Acid and Cardiovascular Risk of the Italian Society of Hypertension (SIIA)
University of Naples Federico II · ITUniversity of Pisa · ITUniversity of Milano-Bicocca · ITOspedale Policlinico San Martino · ITSapienza University of Rome · ITUniversity of Bari Aldo Moro · ITUniversity of Padua · ITAzienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda · ITUniversity of Bologna · ITUniversity of Brescia · ITUniversity of Florence · ITUniversity of L'Aquila · ITCa' Foncello Hospital · ITIstituto di Fisiologia Clinica · ITOspedale Santa Maria della Misericordia di Rovigo · ITSocietà Italiana di Medicina Generale · ITUniversity of Insubria · ITUniversity of Milan · ITUniversity of Palermo · ITUniversity of Perugia · IT
Funding
Italian Society of Arterial Hypertension International Grant 2022
Abstract
High serum uric acid (SUA) and triglyceride (TG) levels might promote high-cardiovascular risk phenotypes across the cardiometabolic spectrum. However, SUA predictive power in the presence of normal and high TG levels has never been investigated. We included 8124 patients from the URic acid Right for heArt Health (URRAH) study cohort who were followed for over 20 years and had no established cardiovascular disease or uncontrolled metabolic disease. All-cause mortality (ACM) and cardiovascular mortality (CVM) were explored by the Kaplan-Meier estimator and Cox multivariable regression, adopting recently defined SUA cut-offs for ACM (≥4.7 mg/dL) and CVM (≥5.6 mg/dL). Exploratory analysis across cardiometabolic subgroups and a sensitivity analysis using SUA/serum creatinine were performed as validation. SUA predicted ACM (HR 1.25 [1.12-1.40],
Indexed as
cardiometaboliccardiovascularhypertriglyceridemiamortalityrisk predictionserum uric acidtriglycerides
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