Evidence map›Paper›PMID 36838701›Full record

ArticleMolecules (Basel, Switzerland)2023

Antimalarial Activity of Tri- and Tetra-Substituted Anilino Pyrazoles.

Matteo Lusardi, Nicoletta Basilico, Chiara Rotolo, Silvia Parapini, Andrea Spallarossa

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
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  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Matteo LusardiDepartment of Pharmacy, University of Genova, Viale Benedetto XV, 3, 16132 Genova, Italy.ORCID 0000-0002-7003-7891
Nicoletta BasilicoDipartimento di Scienze Biomediche, Chirurgiche e Odontoiatriche, Università degli Studi di Milano, 20133 Milan, Italy.ORCID 0000-0001-9030-1066
Chiara RotoloDepartment of Pharmacy, University of Genova, Viale Benedetto XV, 3, 16132 Genova, Italy.
Silvia ParapiniDipartimento di Scienze Biomediche per la Salute, Università degli Studi di Milano, 20133 Milan, Italy.ORCID 0000-0003-2079-8892
Andrea SpallarossaDepartment of Pharmacy, University of Genova, Viale Benedetto XV, 3, 16132 Genova, Italy.ORCID 0000-0002-3360-7146

Funding

University of Genoa Fondo di Ricerca di Ateneo (FRA)
6 · The paper itself

Abstract

Pyrazole core represents a privilege scaffold in medicinal chemistry; a number of pyrazole compounds are endowed with various pharmacological activities in different therapeutic areas including antimalarial treatment. Supported by this evidence, a series of 5-anilino-3-(hetero)arylpyrazoles were evaluated for their antiplasmodial activity in in vitro assays. The compounds were synthesized according to regioselective and versatile protocols that combine active methylene reagents, aryl isothiocyanates and (substituted)hydrazines. The considered derivatives

Indexed as

AntimalarialsChloroquineIndicators and ReagentsPlasmodium falciparumStructure-Activity RelationshipAntimalarialsChloroquineIndicators and Reagentsantiplasmodial activitypyrazolesregioselective synthesisstructure–activity relationships

Identifiers

PMID36838701
PMCPMC9964722

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.