Evidence map›Paper›PMID 36838752›Full record

ReviewMolecules (Basel, Switzerland)2023

A Comprehensive Overview of the Antibiotics Approved in the Last Two Decades: Retrospects and Prospects.

Zhenfeng Shi, Jie Zhang, Lei Tian, Liang Xin, Chengyuan Liang, Xiaodong Ren, Min Li

Erratum issuedAbstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Gemifloxacin resistance inMicrobiology spectrum · 2026
    Article
  6. Article
  7. Some Newer Antibiotics Active AgainstAntibiotics (Basel, Switzerland) · 2026
    Review
  8. Article
  9. Review
  10. Review
  11. Review
  12. Lipopolysaccharide-targeting treatments for multidrug-resistantExpert opinion on therapeutic targets · 2026
    Review
  13. Review
  14. Article
  15. Antimicrobial Resistance: The Answers.British journal of biomedical science · 2026
    Review
  16. Frontiers in microbiology · 2026
    Article
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Zhenfeng ShiDepartment of Urology Surgery Center, Xinjiang Uyghur People's Hospital, Urumqi 830002, China.
Jie ZhangDepartment of Urology Surgery Center, Xinjiang Uyghur People's Hospital, Urumqi 830002, China.
Lei TianDepartment of Urology Surgery Center, Xinjiang Uyghur People's Hospital, Urumqi 830002, China.
Liang XinFaculty of Pharmacy, Shaanxi University of Science & Technology, Xi'an 710021, China.
Chengyuan LiangFaculty of Pharmacy, Shaanxi University of Science & Technology, Xi'an 710021, China.ORCID 0000-0001-7360-8998
Xiaodong RenMedical College, Guizhou University, Guiyang 550025, China.ORCID 0000-0002-1438-6173
Min LiCollege of Pharmacy, Xinjiang Medical University, Urumqi 830054, China.

Funding

Science and technology project of Xi 'an, Shaanxi Province Grant No. 22GXFW0006the Basic Research Program of Natural Science of Shaanxi Province Grant No. 2020CGXNG-044the "Double Chain Integration" Young and Middle-aged Scientific Research Innovation Team of Shaanxi Provincial Administration of Traditional Chinese Medicine Grant No. 2022-SLRH-YQ-009the Education Department Service local special project of Shaanxi Province Grant No. 22JC012the Key Scientific Research Project of Traditional Chinese Medicine Inheritance and Innovation & "Qin Medicine" Development of Shaanxi Provincial Administration of Traditional Chinese Medicine Grant No. 2021-02-220-020the National Natural Science Foundation of China Grant No. 81602967the Qin Chuang yuan TCM innovation research and development project of Shaanxi Provincial Administration of Traditional Chinese Medicine Grant No. 2022-QCYZH-013the Qin Chuang yuan TCM innovation research and development project of Shaanxi Provincial Administration of Traditional Chinese Medicine Grant No. 2022-QCYZH-032the Qin Chuang yuan TCM innovation research and development project of Shaanxi Provincial Administration of Traditional Chinese Medicine Grant No. 2022-QCYZH-033Xinjiang natural science foundation for distinguished young scholars 2022D01E84
6 · The paper itself

Abstract

Due to the overuse of antibiotics, bacterial resistance has markedly increased to become a global problem and a major threat to human health. Fortunately, in recent years, various new antibiotics have been developed through both improvements to traditional antibiotics and the discovery of antibiotics with novel mechanisms with the aim of addressing the decrease in the efficacy of traditional antibiotics. This manuscript reviews the antibiotics that have been approved for marketing in the last 20 years with an emphasis on the antibacterial properties, mechanisms, structure-activity relationships (SARs), and clinical safety of these antibiotics. Furthermore, the current deficiencies, opportunities for improvement, and prospects of antibiotics are thoroughly discussed to provide new insights for the design and development of safer and more potent antibiotics.

Indexed as

Anti-Bacterial AgentsBacterial InfectionsHumansStructure-Activity RelationshipAnti-Bacterial Agentsaminoglycosidesantibacterial resistanceoxazolidinedionepleuromutilinstructure–activity relationships (SARs)superbugs

Identifiers

PMID36838752
PMCPMC9962477

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.