Evidence map›Paper›PMID 36839289›Full record

ArticleNutrients2023

Purine Intake and All-Cause Mortality in Ovarian Cancer: Results from a Prospective Cohort Study.

Zongda Du, Tingting Gong, Yifan Wei, Gang Zheng, Junqi Zhao, Bingjie Zou, Xue Qin, Shi Yan, Fanghua Liu, Qian Xiao and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Metabolomics Analysis on the Effect ofAntioxidants (Basel, Switzerland) · 2025
    Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Zongda DuDepartment of Clinical Epidemiology, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Shenyang 110001, China.
Tingting GongDepartment of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Shenyang 110001, China.
Yifan WeiDepartment of Clinical Epidemiology, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Shenyang 110001, China.
Gang ZhengDepartment of Clinical Epidemiology, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Shenyang 110001, China.
Junqi ZhaoDepartment of Clinical Epidemiology, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Shenyang 110001, China.
Bingjie ZouDepartment of Clinical Epidemiology, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Shenyang 110001, China.
Xue QinDepartment of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Shenyang 110001, China.
Shi YanDepartment of Clinical Epidemiology, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Shenyang 110001, China.
Fanghua LiuDepartment of Clinical Epidemiology, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Shenyang 110001, China.
Qian XiaoDepartment of Clinical Epidemiology, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Shenyang 110001, China.
Qijun WuDepartment of Clinical Epidemiology, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Shenyang 110001, China.ORCID 0000-0001-9421-5114
Song GaoDepartment of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Shenyang 110001, China.
Yuhong ZhaoDepartment of Clinical Epidemiology, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Shenyang 110001, China.

Funding

Gao S Clinical Research Cultivation Project of Shengjing hospitalGong TT 345 Talent Project of Shengjing Hospital of China Medical UniversityGong TT No.82103914Wu QJ No. 2022YFC2704200Zhao YH No. 2021JH1/1040050
6 · The paper itself

Abstract

backgroundCurrent biological evidence suggests that purine involvement in purine metabolism may contribute to the development and progression of ovarian cancer (OC), but the epidemiological association is currently unknown.

methodsA total of 703 newly diagnosed patients with OC aged 18-79 years were included in this prospective cohort study. Utilizing a verified food-frequency questionnaire, the participants' dietary consumption was gathered. Using medical records and ongoing follow-up, the deaths up until 31 March 2021 were determined. To assess the hazard ratios (HRs) and 95% confidence intervals (CIs) of purine intake with OC mortality, Cox proportional-hazard models were utilized.

resultsDuring the median follow-up of 31 months (interquartile: 20-47 months), 130 deaths occurred. We observed an improved survival for the highest tercile of total purine intake compared with the lowest tercile (HR = 0.39, 95% CI = 0.19-0.80;

conclusionA high total purine and xanthine intake was linked to a lower risk of OC mortality. Further clarification of these findings is warranted.

Indexed as

DietOvarian NeoplasmsFemaleHumansProportional Hazards ModelsProspective StudiesPurinesRisk FactorsXanthinesPurinesXanthinescohort studydietmortalityovarian cancerpurine

Identifiers

PMID36839289
PMCPMC9965699

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.