Evidence map›Paper›PMID 36839868›Full record

ReviewPharmaceutics2023

Nanomedicine for Combination Urologic Cancer Immunotherapy.

Yun Tian, Zhenzhu Liu, Jianbo Wang, Linan Li, Fuli Wang, Zheng Zhu, Xuejian Wang

Open access · goldAbstract readReview
In one paragraph

Review in Pharmaceutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
10.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Review
  6. Nanomedicine in Bladder Cancer Therapy.International journal of molecular sciences · 2024
    Review
  7. Role of NOncology reports · 2024
    Review
  8. Review
  9. Article
  10. Review
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Yun TianDepartment of Urology, The First Affiliated Hospital of Dalian Medical University, Dalian 116021, China.
Zhenzhu LiuDepartment of Cardiovascular, The Second Affiliated Hospital of Dalian Medical University, Dalian 116023, China.
Jianbo WangDepartment of Urology, The First Affiliated Hospital of Dalian Medical University, Dalian 116021, China.
Linan LiDepartment of Orthopedics, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, China.
Fuli WangDepartment of Urology, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
Zheng ZhuDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Xuejian WangDepartment of Urology, The First Affiliated Hospital of Dalian Medical University, Dalian 116021, China.
First Affiliated Hospital of Dalian Medical University · CNDalian Medical University · CNAir Force Medical University · CNBrigham and Women's Hospital · US

Funding

National Natural Science Foundation 579 of China No.82173121
6 · The paper itself

Abstract

Urologic cancers, particularly kidney, bladder, and prostate cancer, have a growing incidence and account for about a million annual deaths worldwide. Treatments, including surgery, chemotherapy, radiotherapy, hormone therapy, and immunotherapy are the main therapeutic options in urologic cancers. Immunotherapy is now a clinical reality with marked success in solid tumors. Immunological checkpoint blockade, non-specific activation of the immune system, adoptive cell therapy, and tumor vaccine are the main modalities of immunotherapy. Immunotherapy has long been used to treat urologic cancers; however, dose-limiting toxicities and low response rates remain major challenges in the clinic. Herein, nanomaterial-based platforms are utilized as the "savior". The combination of nanotechnology with immunotherapy can achieve precision medicine, enhance efficacy, and reduce toxicities. In this review, we highlight the principles of cancer immunotherapy in urology. Meanwhile, we summarize the nano-immune technology and platforms currently used for urologic cancer treatment. The ultimate goal is to help in the rational design of strategies for nanomedicine-based immunotherapy in urologic cancer.

Indexed as

immune checkpoint inhibitorsimmunotherapynanomedicineurologic cancer

Identifiers

PMID36839868
PMCPMC9960671
OpenAlexW4319442266

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.