Evidence map›Paper›PMID 36843073›Full record

ArticleGut microbes

Circulating androgen regulation by androgen-catabolizing gut bacteria in male mouse gut.

Tsun-Hsien Hsiao, Chia-Hong Chou, Yi-Lung Chen, Po-Hsiang Wang, Guo-Jie Brandon-Mong, Tzong-Huei Lee, Tien-Yu Wu, Po-Ting Li, Chen-Wei Li, Yi-Li Lai and 5 more

Open access · goldAbstract read
In one paragraph

Article in Gut microbes. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Links between bone fractures and the gut microbiota.Nature reviews. Endocrinology · 2026
    Review
  5. Review
  6. Review
  7. Review
  8. Review
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Bacterial estrogenesis without oxygen: Wood-Ljungdahl pathway likely contributed to the emergence of estrogens in the biosphere.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 2 countries.

Tsun-Hsien HsiaoBiodiversity Research Center, Academia Sinica, Taipei, Taiwan.ORCID 0000-0003-2002-2760
Chia-Hong ChouDepartment of Obstetrics and Gynecology, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan.
Yi-Lung ChenDepartment of Microbiology, Soochow University, Taipei, Taiwan.ORCID 0000-0001-7840-7423
Po-Hsiang WangGraduate Institute of Environmental Engineering, National Central University, Taoyuan City, Taiwan.ORCID 0000-0001-9900-0972
Guo-Jie Brandon-MongBiodiversity Research Center, Academia Sinica, Taipei, Taiwan.ORCID 0000-0002-1673-8021
Tzong-Huei LeeInstitute of Fisheries Science, National Taiwan University, Taipei, Taiwan.
Tien-Yu WuBiodiversity Research Center, Academia Sinica, Taipei, Taiwan.
Po-Ting LiDepartment of Obstetrics and Gynecology, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan.
Chen-Wei LiBiodiversity Research Center, Academia Sinica, Taipei, Taiwan.
Yi-Li LaiBiodiversity Research Center, Academia Sinica, Taipei, Taiwan.
Yu-Lin TsengDepartment of Obstetrics and Gynecology, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan.
Chao-Jen ShihBioresource Collection and Research Center, Food Industry Research and Development Institute, Hsinchu, Taiwan.ORCID 0000-0001-7791-8264
Po-Hao ChenDepartment of Microbiology, Soochow University, Taipei, Taiwan.
Mei-Jou ChenDepartment of Obstetrics and Gynecology, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan.ORCID 0000-0002-2305-1105
Yin-Ru ChiangBiodiversity Research Center, Academia Sinica, Taipei, Taiwan.ORCID 0000-0001-6899-3166
Biodiversity Research Center, Academia Sinica · TWNational Taiwan University · TWNational Taiwan University Hospital · TWSoochow University · TWFood Industry Research and Development Institute · TWTokyo Institute of Technology · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Abnormally high circulating androgen levels have been considered a causative factor for benign prostatic hypertrophy and prostate cancer in men. Recent animal studies on gut microbiome suggested that gut bacteria are involved in sex steroid metabolism; however, the underlying mechanisms and bacterial taxa remain elusive. Denitrifying betaproteobacteria

Indexed as

AndrogensGastrointestinal MicrobiomeAnimalsBacteriaLipid MetabolismMaleMiceMice, Inbred C57BLAndrogensAndrogengut microbehyperandrogenismmousesex steroidstestosterone catabolismthauera

Identifiers

PMID36843073
PMCPMC9980454
OpenAlexW4322216952

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.