Evidence map›Paper›PMID 36845124›Full record

ArticleFrontiers in immunology2023

ROCKETS - a novel one-for-all toolbox for light sheet microscopy in drug discovery.

Joerg P J Mueller, Michael Dobosz, Nils O'Brien, Nassri Abdoush, Anna Maria Giusti, Martin Lechmann, Franz Osl, Ann-Katrin Wolf, Estibaliz Arellano-Viera, Haroon Shaikh and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Joerg P J MuellerInterdisciplinary Center for Clinical Research Laboratory (IZKF) Würzburg, Department of Internal Medicine II, Center for Experimental Molecular Medicine, Würzburg University Hospital, Würzburg, Germany.
Michael DoboszPharmaceutical Research and Early Development, Roche Diagnostics GmbH, Penzberg, Germany.
Nils O'BrienPharmaceutical Research and Early Development, Roche Diagnostics GmbH, Penzberg, Germany.
Nassri AbdoushPharmaceutical Research and Early Development, Roche Diagnostics GmbH, Penzberg, Germany.
Anna Maria GiustiRoche Pharmaceutical Research and Early Development, Roche Glycart AG, Schlieren, Switzerland.
Martin LechmannPharmaceutical Research and Early Development, Roche Diagnostics GmbH, Penzberg, Germany.
Franz OslPharmaceutical Research and Early Development, Roche Diagnostics GmbH, Penzberg, Germany.
Ann-Katrin WolfInterdisciplinary Center for Clinical Research Laboratory (IZKF) Würzburg, Department of Internal Medicine II, Center for Experimental Molecular Medicine, Würzburg University Hospital, Würzburg, Germany.
Estibaliz Arellano-VieraInterdisciplinary Center for Clinical Research Laboratory (IZKF) Würzburg, Department of Internal Medicine II, Center for Experimental Molecular Medicine, Würzburg University Hospital, Würzburg, Germany.
Haroon ShaikhInterdisciplinary Center for Clinical Research Laboratory (IZKF) Würzburg, Department of Internal Medicine II, Center for Experimental Molecular Medicine, Würzburg University Hospital, Würzburg, Germany.
Markus SauerDepartment of Biotechnology and Biophysics, Biocenter, University of Würzburg, Würzburg, Germany.
Andreas RosenwaldInstitute of Pathology, University of Würzburg, Würzburg, Germany.
Frank HertingPharmaceutical Research and Early Development, Roche Diagnostics GmbH, Penzberg, Germany.
Pablo UmañaRoche Pharmaceutical Research and Early Development, Roche Glycart AG, Schlieren, Switzerland.
Sara ColombettiRoche Pharmaceutical Research and Early Development, Roche Glycart AG, Schlieren, Switzerland.
Thomas PöschingerPharmaceutical Research and Early Development, Roche Diagnostics GmbH, Penzberg, Germany.
Andreas BeilhackInterdisciplinary Center for Clinical Research Laboratory (IZKF) Würzburg, Department of Internal Medicine II, Center for Experimental Molecular Medicine, Würzburg University Hospital, Würzburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Advancing novel immunotherapy strategies requires refined tools in preclinical research to thoroughly assess drug targets, biodistribution, safety, and efficacy. Light sheet fluorescence microscopy (LSFM) offers unprecedented fast volumetric

Indexed as

Drug DiscoveryReceptor Protein-Tyrosine KinasesAnimalsEpithelial Cell Adhesion MoleculeHumansMiceMicroscopy, FluorescencePhosphorylationTissue DistributionEpithelial Cell Adhesion MoleculeReceptor Protein-Tyrosine KinasesbiodistributioncancerEpCAM (CD326)imagingimmunotherapylight sheet fluorescence microscopypreclinical drug development

Identifiers

PMID36845124
PMCPMC9945347

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.