Evidence map›Paper›PMID 36846150›Full record

ArticleFrontiers in neurology2023

Effect of botulinum toxin type A on non-motor symptoms and quality of life in Meige syndrome.

Heqing Zheng, Lanxiang Wu, Sheng Tian, Mingxu Liu, Qingqing Zhan, Xinping Yu, Yonggang Xie, Xianhui Zhong, Wei Wu

Abstract read
In one paragraph

Article in Frontiers in neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Investigating Sleep Concerns in Cervical Dystonia.Movement disorders clinical practice · 2026
    Article
  2. [Meige syndrome with dyspnea as main manifestation: a report of one case and literature review].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2025
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Heqing ZhengDepartment of Neurology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Lanxiang WuDepartment of Neurology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Sheng TianDepartment of Neurology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Mingxu LiuDepartment of Neurology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Qingqing ZhanDepartment of Neurology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Xinping YuDepartment of Neurology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Yonggang XieDepartment of Neurology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Xianhui ZhongDepartment of Neurology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Wei WuDepartment of Neurology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: It has been shown in previous studies that botulinum toxin type A (BTX-A) can effectively relieve the motor symptoms of Meige syndrome. However, its effect on non-motor symptoms (NMS) and quality of life (QoL) has not been comprehensively studied. This study aimed to explore the effects of BTX-A on NMS and QoL and to clarify the relationship between changes in motor symptoms, NMS, and QoL after BTX-A. Methods: Seventy-five patients were recruited for the study. All patients were assessed by a series of clinical assessments before, one, and 3 months after BTX-A treatment. Dystonic symptoms, psychiatric disturbances, sleep disorders, and QoL were evaluated. Results: After 1 and 3 months of BTX-A treatment, the scores of motor symptoms, anxiety, and depression were significantly decreased ( Conclusions: BTX-A effectively improved motor symptoms, anxiety, depression, and QoL. Anxiety and depression improvement did not correlate with motor symptom changes after BTX-A, and QoL improvements were strongly associated with psychiatric disturbances.

Indexed as

botulinum toxinMeige syndromenon-motor symptomspsychiatric disturbancesquality of life

Identifiers

PMID36846150
PMCPMC9947842

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.