ArticleFrontiers in psychiatry2023
Impairment of GABA inhibition in insomnia disorders: Evidence from the peripheral blood system.
Article in Frontiers in psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Efficacy and Safety ofNutrients · 2026Trial
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- Effects of Melatonin Formulations on Caffeine-Evoked Cortical Activity and Pentobarbital-Induced Sleep in Mice.International journal of molecular sciences · 2026Article
- Safety, Sedative, and Anxiolytic Evaluation of MECS Hard Capsules Using In Silico and In Vivo Approaches.ACS omega · 2026Article
- Insomnia Pathogenesis and Multidimensional Mechanisms of Acupuncture: A Narrative Review.International journal of general medicine · 2026Review
- Adolescent Insomnia Disorder - Problematic Internet Use Nexus: A Convergent Developmental Trajectory - Bridging Neuroimaging Biomarkers, Molecular Susceptibility, and Environmental-Neurocognitive Cascades.Psychology research and behavior management · 2026Review
- Causal Effects of Gut Microbiota on Morning Chronotype, Insomnia and Sleep Duration: A Two-Sample Mendelian Randomization Study.Journal of central nervous system disease · 2026Article
- Generalized Anxiety Disorder and Obesity: Overlapping Neuroendocrine, Metabolic, and Behavioral Pathways.Nutrients · 2025Review
- Extraction Methods and Sedative-Hypnotic Effects of Total Flavonoids fromPharmaceuticals (Basel, Switzerland) · 2025Article
- GABAergic Signaling Underlying REM Sleep Deprivation-Induced Spatial Working Memory Deficits.Brain and behavior · 2025Article
- Study on the correlation between insomnia degree and quality of life in psychiatric outpatients in Chifeng city.World journal of psychiatry · 2025Article
- Characterizing Genetic-Predisposed Proteins Involving Insomnia by Integrating Genome-Wide Association Study Summary Statistics.Molecular neurobiology · 2025Article
- Impact of Ambient Air Pollution on Obstructive Sleep Apnea Surgery: A Longitudinal Study.ORL; journal for oto-rhino-laryngology and its related specialties · 2025Article
- From the gut to the brain, mechanisms and clinical applications of γ-aminobutyric acid (GABA) on the treatment of anxiety and insomnia.Frontiers in neuroscience · 2025Review
- Electroacupuncture as adjunctive therapy for insomnia via targeting the GABAergic microbiota-gut-brain axis: a mini review.Frontiers in psychiatry · 2025Review
- Insomnia treatment based on the regulation of the GABAergic system: traditional Chinese medicine perspectives and therapeutic approaches.Frontiers in neuroscience · 2025Review
- The Effect of Water-Soluble Alpinia Galanga Extract on Sleep and the Activation of the GABAAergic/Serotonergic Pathway in Mice.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Research progress on the effect of medicine and food homology resources for sleep improvement.Heliyon · 2024Review
- Contributions of Gamma-Aminobutyric Acid (GABA) Produced by Lactic Acid Bacteria on Food Quality and Human Health: Current Applications and Future Prospects.Foods (Basel, Switzerland) · 2024Review
- Prolonged Zaleplon Treatment Increases the Expression of Proteins Involved in GABAergic and Glutamatergic Signaling in the Rat Hippocampus.Brain sciences · 2023Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aim: To explore the change characteristics and related factors of various indexes of GABAergic system in peripheral blood of patients with insomnia disorder. Methods: In this study, a total of 30 patients who met the DSM-5 diagnostic criteria for insomnia disorder and 30 normal controls were included. All subjects had a structured clinical interview with the Brief International Neuropsychiatric Disorder Interview, and PSQI was used to evaluate the sleep status of the subjects. Enzyme-linked immunosorbent assay (ELISA) was used to detect serum γ-aminobutyric acid (GABA), and RT-PCR was used to detect GABA Results: Compared with the normal control group, the mRNA levels of GABA Conclusion: The inhibitory function of serum GABA in patients with insomnia may be impaired, and the decreased expression levels of GABA
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