Evidence map›Paper›PMID 36846334›Full record

ArticleFrontiers in physiology2023

Impairment of β-adrenergic regulation and exacerbation of pressure-induced heart failure in mice with mutations in phosphoregulatory sites in the cardiac Ca

Liam Hovey, Xiaoyun Guo, Yi Chen, Qinghang Liu, William A Catterall

Open access · goldAbstract read
In one paragraph

Article in Frontiers in physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Liam HoveyDepartment of Pharmacology, School of Medicine, University of Washington, Seattle, WA, United States.
Xiaoyun GuoDepartment of Physiology and Biophysics, School of Medicine, University of Washington, Seattle, WA, United States.
Yi ChenDepartment of Physiology and Biophysics, School of Medicine, University of Washington, Seattle, WA, United States.
Qinghang LiuDepartment of Physiology and Biophysics, School of Medicine, University of Washington, Seattle, WA, United States.
William A CatterallMedical Scientist Training Program, School of Medicine, University of Washington, Seattle, WA, United States.
University of Washington · USUniversity of Washington Medical Center · US

Funding

EXPERIMENTAL PATHOLOGY OF CARDIOVASCULAR DISEASET32HL007312 · NHLBI · UNIVERSITY OF WASHINGTON · PI MAJESKY, MARK W., SCHWARTZ, STEPHEN MARK · 1985 to 2019
$11.8M
NRSA Training CoreTL1TR002318 · NCATS · UNIVERSITY OF WASHINGTON · PI Megan Moore · 2017 to 2026
$8.4M
Structural Basis for Antiarrhythmic Drug ActionR01HL112808 · NHLBI · UNIVERSITY OF WASHINGTON · PI ZHENG, NING · 2012 to 2025
$7.8M
Sodium and Calcium Channels: Structure, Function, Neuroplasticity, and DiseaseR35NS111573 · NINDS · UNIVERSITY OF WASHINGTON · PI SCOTT, JOHN D · 2019 to 2024
$6.1M
A K63-Ubiquitination Dependent Necroptosis Signaling Network in the HeartR01HL155035 · NHLBI · UNIVERSITY OF WASHINGTON · PI LIU, QINGHANG · 2021 to 2025
$1.9M
The Deubiquitinase CYLD Controls Multiple Cell Death Pathways in the HeartR01HL160767 · NHLBI · UNIVERSITY OF WASHINGTON · PI LIU, QINGHANG · 2022 to 2025
$1.6M
NCATS NIH HHS TL1 TR002318NHLBI NIH HHS R01 HL112808NHLBI NIH HHS R01 HL155035NHLBI NIH HHS R01 HL160767NHLBI NIH HHS T32 HL007312NINDS NIH HHS R35 NS111573
6 · The paper itself

Abstract

The cardiac calcium channel Ca

Indexed as

adrenergiccAMP-dependentchronic heart failurefight-or-flightisoproterenolprotein phosphorylationtransverse aortic constrictionvoltage-gated calcium channel

Identifiers

PMID36846334
PMCPMC9944942
OpenAlexW4319602366

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.