ArticleEuropean journal of heart failure2023
Left atrial enlargement is associated with pulmonary vascular disease in heart failure with preserved ejection fraction.
Article in European journal of heart failure, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 17 citations in OpenAlex.
- Review
- Development of a Noninvasive Prediction Score for Post-Capillary Pulmonary Hypertension in a Multi-Ethnic Asian Population.JACC. Asia · 2026Article
- Plasma proteins and mechanisms involved in the evolvement of cardiac function after myocardial infarction.Scientific reports · 2026Article
- Subtle echocardiographic markers of CAD: looking beyond the LV ejection fraction in stable angina patients.Clinical research in cardiology : official journal of the German Cardiac Society · 2025Article
- Association of Left Atrial Dysfunction with Pulmonary Hemodynamics and Cardiovascular Outcomes in Patients with Systemic Sclerosis.CJC open · 2025Article
- 2024 update in heart failure.ESC heart failure · 2025Review
- Comparing Left Atrial Strain and the HFA-PEFF Score in Diagnosing Heart Failure with Preserved Ejection Fraction: A Cross-Sectional Study.Research in heart yield and translational medicine · 2025Article
- Risk factors and clinical prediction models for prolonged mechanical ventilation after heart valve surgery.BMC cardiovascular disorders · 2024Article
- Clinical-imaging-pathological correlation in pulmonary hypertension associated with left heart disease.European respiratory review : an official journal of the European Respiratory Society · 2024Article
- The role of uromodulin in cardiovascular disease: a review.Frontiers in cardiovascular medicine · 2024Review
- Active left atrial ejection fraction as a non-invasive marker in pulmonary hypertension secondary to heart failure.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2024Article
- Omics and Extreme Phenotyping Reveal Longitudinal Association Between Left Atrial Size and Pulmonary Vascular Resistance in Group 2 Pulmonary Hypertension.Journal of the American Heart Association · 2023Article
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Authors and funding
14 authors at 10 institutions in 3 countries.
Funding
Abstract
aimsElevated left atrial (LA) pressure is a pathophysiologic hallmark of heart failure with preserved ejection fraction (HFpEF). Chronically elevated LA pressure leads to LA enlargement, which may impair LA function and increase pulmonary pressures. We sought to evaluate the relationship between LA volume and pulmonary arterial haemodynamics in patients with HFpEF. METHODS AND
resultsData from 85 patients (aged 69 ± 8 years) who underwent exercise right heart catheterization and echocardiography were retrospectively analysed. All had symptoms of heart failure, left ventricular ejection fraction ≥50% and haemodynamic features of HFpEF. Patients were divided into LA volume index-based tertiles (≤34 ml/m
conclusionIncreasing LA volume may be associated with more advanced pulmonary vascular disease in HFpEF, featuring higher PVR and pulmonary pressures. Reduced LA function, worse at increasing LA volumes, is associated with a disrupted PVR-compliance relationship, further augmenting impaired pulmonary haemodynamics.
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