Evidence map›Paper›PMID 36847244›Full record

ArticleAmerican journal of rhinology & allergy2023

The Nasal Innate Immune Proteome After Saline Irrigation: A Pilot Study in Healthy Individuals.

Emily A Harcourt-Smith, Emerson T Krstic, Belinda J Soekov-Pearce, Alex D Colella, Nusha Chegeni, Timothy K Chataway, Charmaine M Woods, Kamelya Aliakbari, A Simon Carney

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of rhinology & allergy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Emily A Harcourt-SmithCollege of Medicine and Public Health, Flinders University, Bedford Park, SA, Australia.ORCID 0000-0001-6400-1131
Emerson T KrsticCollege of Medicine and Public Health, Flinders University, Bedford Park, SA, Australia.
Belinda J Soekov-PearceCollege of Medicine and Public Health, Flinders University, Bedford Park, SA, Australia.
Alex D ColellaProteomics Facility, College of Medicine and Public Health, Flinders University, Bedford Park, SA, Australia.
Nusha ChegeniProteomics Facility, College of Medicine and Public Health, Flinders University, Bedford Park, SA, Australia.
Timothy K ChatawayProteomics Facility, College of Medicine and Public Health, Flinders University, Bedford Park, SA, Australia.
Charmaine M WoodsCollege of Medicine and Public Health, Flinders University, Bedford Park, SA, Australia.
Kamelya AliakbariProteomics Facility, College of Medicine and Public Health, Flinders University, Bedford Park, SA, Australia.
A Simon CarneyCollege of Medicine and Public Health, Flinders University, Bedford Park, SA, Australia.ORCID 0000-0001-7507-7983
Flinders University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPrevious research has shown diminished nasal immune function following nasal saline irrigation (NSI), returning to baseline at 6 hours. The aim of this study was to examine the immune nasal proteome before and after 14 days of nasal irrigation.

methodsSeventeen healthy volunteers received either isotonic (IsoSal) or low salt (LowNa) NSI. Nasal secretions were collected before and 30 min after NSI at baseline and again after 14 days. Specimens were analyzed using mass spectrometry to detect proteins of relevance to nasal immune function.

resultsOne thousand eight hundred and sixty-five proteins were identified with significant changes in 71 proteins, of which 23 were identified as part of the innate immune system. Baseline analysis demonstrated an increase of 9 innate proteins after NSI, most after IsoSal. After 14 days, a greater increase in innate peptides was present, with most now in the LowNa group. When NSI solutions were compared, a significant increase in 4 innate proteins, including a 211% in lysozyme, was detected in the LowNa group.

conclusionLowNa NSI demonstrates evidence of improving the innate immune secretions, especially lysozyme, in healthy volunteers.

Indexed as

RhinitisSinusitisHumansImmunity, InnateMuramidaseNasal LavagePilot ProjectsProteomeSaline SolutionTherapeutic IrrigationMuramidaseProteomeSaline Solutioninnate immunityintranasal administrationlactoferrinlysozymemass spectrometrynasal mucosaproteomicsrhinitissaline solutionsinusitis

Identifiers

PMID36847244
PMCPMC10273869
OpenAlexW4322496034

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.