Evidence map›Paper›PMID 36848288›Full record

ArticleCell reports2023

Phenotypic heterogeneity in the bacterial oxidative stress response is driven by cell-cell interactions.

Divya Choudhary, Valentine Lagage, Kevin R Foster, Stephan Uphoff

Abstract read
In one paragraph

Article in Cell reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed.

  1. Article
  2. Review
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  4. Periplasmic detoxification of urate hydroperoxide underpinsbioRxiv : the preprint server for biology · 2026
    Article
  5. Review
  6. Article
  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Divya ChoudharyDepartment of Biochemistry, University of Oxford, Oxford, UK.
Valentine LagageDepartment of Biochemistry, University of Oxford, Oxford, UK.
Kevin R FosterDepartment of Biochemistry, University of Oxford, Oxford, UK; Department of Biology, University of Oxford, Oxford, UK.
Stephan UphoffDepartment of Biochemistry, University of Oxford, Oxford, UK. Electronic address: stephan.uphoff@bioch.ox.ac.uk.

Funding

Wellcome TrustWellcome Trust 206159/Z/17/BWellcome Trust 206159/Z/17/ZWellcome Trust 209397/Z/17/Z
6 · The paper itself

Abstract

Genetically identical bacterial cells commonly display different phenotypes. This phenotypic heterogeneity is well known for stress responses, where it is often explained as bet hedging against unpredictable environmental threats. Here, we explore phenotypic heterogeneity in a major stress response of Escherichia coli and find it has a fundamentally different basis. We characterize the response of cells exposed to hydrogen peroxide (H

Indexed as

Hydrogen PeroxideOxidative StressBacteriaCell CommunicationOxidation-ReductionPhenotypeHydrogen Peroxidebacterial gene regulationcell-cell interactionsCP: Microbiologymachine learningoxidative stressphenotypic heterogeneitysingle-cell imagingstress response

Identifiers

PMID36848288
PMCPMC10935545

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.