ReviewProgress in cardiovascular diseases
Exercise as a therapeutic modality for the prevention and treatment of depression.
Review in Progress in cardiovascular diseases. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 3 syntheses or guidelines pooled it, 80 citations in OpenAlex.
- Physical Activity interventions on health-related quality of life (HR-QoL) in major depressive disorder (MDD): a systematic review and meta-analysis of randomized controlled trials.Frontiers in psychiatry · 2026Pooled it
- Effectiveness of different exercise interventions on depressive symptoms among college students: a network meta-analysis.BMC public health · 2025Pooled it
- Effect of Latin dance on physical and mental health: a systematic review.BMC public health · 2023Pooled it
- Stationary Cycling Exercise With Virtual Reality to Reduce Depressive Symptoms Among People With Mild to Moderate Depression: Randomized Controlled Trial.Journal of medical Internet research · 2025Trial
- Sports team participation in high school and adolescent and young adult depression and anxiety across sex, race/ethnicity, and socioeconomic status.Journal of research on adolescence : the official journal of the Society for Research on Adolescence · 2026Article
- From depression to bone health: examining the skeletal effects of classical and rapid-acting antidepressants.The international journal of neuropsychopharmacology · 2026Review
- Exercise as an Adjunctive Lifestyle Intervention for Psychiatric Comorbidities in Autism Spectrum Disorder.Journal of autism and developmental disorders · 2026Article
- Hepatic Gluconeogenesis and the Antidepressant Effects of Exercise: A Narrative Review.Metabolites · 2026Review
- Positive effect of physical activity for depression and major depression: a Mendelian randomization study.European archives of psychiatry and clinical neuroscience · 2026Article
- Treadmill exercise alleviates depression in female mice induced by chronic unpredictable mild stress through the Inhibition of cGAS-STING signalling.Scientific reports · 2025Article
- Membrane Trafficking in Psychiatric Disorders: Bridging Cellular Dysfunction and Mental Health-A Narrative Review.Molecular neurobiology · 2025Review
- Clustering of lifestyle factors and the relationship with mental health among college students: a latent profile analysis.BMC public health · 2025Article
- The risk factors of obsessive-compulsive disorder: a cross-sectional study in Southwestern China.BMC psychiatry · 2025Article
- Beyond the Heart: The Significance of Depression in Cardiac Surgery.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2025Review
- [Influence of Exercise Prescription on the Recovery of Cognitive Function In College Students With Mild-to-Moderate Depression].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2025Article
- Meta-analysis of the effects of multimodal physical therapy on improving depression.World journal of psychiatry · 2025Article
- Determinant factors of prolonged hospitalization in acute heart failure patients at Jimma Medical Center, Southwest Ethiopia.Scientific reports · 2025Observational
- Depression, Anxiety, and Quality of Life in a Cardiac Rehabilitation Program Without Dedicated Mental Health Resources Post-Myocardial Infarction.Journal of cardiovascular development and disease · 2025Article
- Exercise-Activated mPFC Tri-Synaptic Pathway Ameliorates Depression-Like Behaviors in Mouse.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- The psychosocial impact of exercise as an intervention for persons living with obesity and female infertility: A rapid scoping review and pilot study.PLOS mental health · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
While maintaining an active lifestyle and engaging in regular exercise are known to promote cardiovascular (CV) health, increasing evidence has emerged to indicate that these lifestyle behaviors also can promote psychological health and well-being. This has led to research to determine if exercise can serve as a potential therapeutic modality for major depressive disorder (MDD), which is a leading cause of mental-health impairment and overall disability worldwide. The strongest evidence to support this use comes from an increasing number of randomized clinical trials (RCTs) that have compared exercise to usual care, placebo controls, or established therapies in healthy adults and in various clinical populations. The relatively large number of RCTs has led to numerous reviews and meta-analyses, which generally have been concordant in indicating that exercise ameliorates depressive symptoms, improves self-esteem, and enhances various aspects of quality of life. Together, these data indicate that exercise should be considered as a therapeutic modality for improving CV health and psychological well-being. The emerging evidence also has led to a new proposed subspecialty of "lifestyle psychiatry", which promotes the use of exercise as an adjunctive treatment for patients with MDD. Indeed, some medical organizations have now endorsed lifestyle-based approaches as foundational aspects of depression management, with adoption of exercise as a treatment option for MDD. This review summarizes research in the area and provides practical suggestions for the use of exercise in clinical practice.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.