Evidence mapPaperPMID 36849261Full record

ArticleeNeuro2023

Physiological Condition-Dependent Changes in Ciliary GPCR Localization in the Brain.

Kathryn M Brewer, Staci E Engle, Ruchi Bansal, Katlyn K Brewer, Kalene R Jasso, Jeremy C McIntyre, Christian Vaisse, Jeremy F Reiter, Nicolas F Berbari

Open access · goldFull text read
In one paragraph

Article in eNeuro, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
5.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
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  10. Review
  11. Article
  12. Neuronal cilia in energy homeostasis.Frontiers in cell and developmental biology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Kathryn M BrewerDepartment of Biology, Indiana University-Purdue University Indianapolis, Indianapolis, Indiana 46202.
Staci E EngleDepartment of Biology, Indiana University-Purdue University Indianapolis, Indianapolis, Indiana 46202.
Ruchi BansalDepartment of Biology, Indiana University-Purdue University Indianapolis, Indianapolis, Indiana 46202.
Katlyn K BrewerDepartment of Biology, Indiana University-Purdue University Indianapolis, Indianapolis, Indiana 46202.
Kalene R JassoDepartment of Neuroscience and Center for Smell and Taste, University of Florida, Gainesville, Florida 32603.
Jeremy C McIntyreDepartment of Neuroscience and Center for Smell and Taste, University of Florida, Gainesville, Florida 32603.ORCID https://orcid.org/0000-0001-8155-7166
Christian VaisseDiabetes Center and Department of Medicine, University of California San Francisco, San Francisco, California 94143.
Jeremy F ReiterDepartment of Biochemistry and Biophysics, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California 94158.
Nicolas F BerbariDepartment of Biology, Indiana University-Purdue University Indianapolis, Indianapolis, Indiana 46202 nberbari@iupui.edu.
Indiana University – Purdue University Indianapolis · USUniversity of California, San Francisco · USUniversity of Florida · USNeurosciences Institute · US

Funding

The Melanocortin-4 Receptor in Human ObesityR01DK060540 · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · 2002 to 2005
$1.3M
Obesity in ciliopathies: How neuronal primary cilia control appetiteR01DK106404 · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2025 to 2025
$955k
How Hedgehog Contributes to Centrally Mediated Energy Homeostasis?R01DK114008 · INDIANA UNIVERSITY INDIANAPOLIS · 2025 to 2025
$500k
NIAMS NIH HHS R01 AR054396NIDA NIH HHS R21 DA047623NIDCD NIH HHS F31 DC019312NIDCR NIH HHS R01 DE029454NIDDK NIH HHS P30 DK098722NIDDK NIH HHS R01 DK060540NIDDK NIH HHS R01 DK106404NIDDK NIH HHS R01 DK114008
6 · The paper itself

Abstract

Primary cilia are cellular appendages critical for diverse types of Signaling. They are found on most cell types, including cells throughout the CNS. Cilia preferentially localize certain G-protein-coupled receptors (GPCRs) and are critical for mediating the signaling of these receptors. Several of these neuronal GPCRs have recognized roles in feeding behavior and energy homeostasis. Cell and model systems, such as

Indexed as

Receptors, G-Protein-CoupledSignal TransductionAnimalsBrainCaenorhabditis elegansMammalsMiceReceptors, G-Protein-Coupledaccumbensfeeding behaviorG-protein-coupled receptorshypothalamusobesityprimary cilia

Identifiers

PMID36849261
PMCPMC10012409
OpenAlexW4322490152

What Socratic holds

Textfull text, public
LicenceCC BY
measurements read40
table measurements read17
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.