Evidence map›Paper›PMID 36849419›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2023

Inducible CRISPR Epigenome Systems Mimic Cocaine Induced Bidirectional Regulation of Nab2 and Egr3.

Eric Y Choi, Daniela Franco, Catherine A Stapf, Madeleine Gordin, Amanda Chow, Kara K Cover, Ramesh Chandra, Mary Kay Lobo

Open access · greenAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Psychiatric Symptoms in Wilson's Disease-Consequence ofInternational journal of molecular sciences · 2024
    Review
  7. Article
  8. Neuroepigenetic Editing.Methods in molecular biology (Clifton, N.J.) · 2024
    Review
  9. Review
  10. Current Status and Future Strategies for Advancing Functional Circuit MappingThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 5 countries.

Eric Y ChoiDepartment of Anatomy and Neurobiology.ORCID 0000-0002-0023-6844
Daniela FrancoDepartment of Anatomy and Neurobiology.
Catherine A StapfDepartment of Anatomy and Neurobiology.
Madeleine GordinDepartment of Anatomy and Neurobiology.
Amanda ChowDepartment of Anatomy and Neurobiology.
Kara K CoverDepartment of Anatomy and Neurobiology.
Ramesh ChandraDepartment of Anatomy and Neurobiology rchandra@som.umaryland.edu mklobo@som.umaryland.edu.
Mary Kay LoboDepartment of Anatomy and Neurobiology rchandra@som.umaryland.edu mklobo@som.umaryland.edu.ORCID 0000-0002-9419-2079
Institute of Neurobiology · BGNeuroscience Institute · ITLife Science Zurich · CHUniversity of Maryland, Baltimore · US

Funding

EXPAND PARTICIPATION BY MINORITIES IN BIOMEDICAL SCIENCER25GM055036 · NIGMS · UNIVERSITY OF MARYLAND BALTIMORE COUNTY · PI SUMMERS, MICHAEL FINLEY · 1996 to 2021
$16.9M
Cocaine-induced mitochondrial mechanisms and molecular mediators in reward circuitryR01DA038613 · NIDA · UNIVERSITY OF MARYLAND BALTIMORE · PI LOBO, MARY KAY · 2014 to 2025
$4.9M
Light activated CRISPR epigenome editing in cocaine abuseR21DA046227 · NIDA · UNIVERSITY OF MARYLAND BALTIMORE · PI LOBO, MARY KAY · 2018 to 2019
$401k
Epigenome Editing in Opioid ActionR21DA052101 · NIDA · UNIVERSITY OF MARYLAND BALTIMORE · PI LOBO, MARY KAY · 2020 to 2021
$386k
Cell Subtype Transcriptional Role of Nab2 in Cocaine Self AdministrationF31DA052967 · NIDA · UNIVERSITY OF MARYLAND BALTIMORE · PI CHOI, ERIC Y · 2021 to 2022
$70k
NIDA NIH HHS F31 DA052967NIDA NIH HHS R01 DA038613NIDA NIH HHS R21 DA046227NIDA NIH HHS R21 DA052101NIGMS NIH HHS R25 GM055036
6 · The paper itself

Abstract

Substance use disorder is a chronic disease and a leading cause of disability around the world. The NAc is a major brain hub mediating reward behavior. Studies demonstrate exposure to cocaine is associated with molecular and functional imbalance in NAc medium spiny neuron subtypes (MSNs), dopamine receptor 1 and 2 enriched D1-MSNs and D2-MSNs. We previously reported repeated cocaine exposure induced transcription factor early growth response 3 (

Indexed as

CocaineCocaine-Related DisordersAnimalsClustered Regularly Interspaced Short Palindromic RepeatsEarly Growth Response Protein 3EpigenomeMaleMiceMice, Inbred C57BLMice, TransgenicNeoplasm ProteinsNucleus AccumbensReceptors, Dopamine D1Receptors, Dopamine D2Repressor ProteinsCocaineEarly Growth Response Protein 3Egr3 protein, mouseNab2 protein, mouseNeoplasm ProteinsReceptors, Dopamine D1Receptors, Dopamine D2Repressor ProteinsaddictioncocaineCRISPRdrugEgr3Nab2

Identifiers

PMID36849419
PMCPMC10072301
OpenAlexW4322490205

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.