Evidence map›Paper›PMID 36849595›Full record

SynthesisClinical oral investigations2023

Laser treatments as an adjunct to non-surgical periodontal therapy in subjects with periodontitis and type 2 diabetes mellitus: a systematic review and meta-analysis.

Stefano Corbella, Elena Calciolari, Nikolaos Donos, Alice Alberti, Pinar Ercal, Luca Francetti

Registry-linked trialAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Clinical oral investigations, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06469294 (Evaluation of Chlorhexidine Gel Associated with Photodynamic Therapy in the Treatment of Chronic Periodontitis in Type 2 Diabetics), which is not on this map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06469294 nacompletednot on this mapstarted 2024, after this paper: background citation

Evaluation of Chlorhexidine Gel Associated with Photodynamic Therapy in the Treatment of Chronic Periodontitis in Type 2 Diabetics

TypeinterventionalSponsorUniversidade Federal FluminenseRan2024 to 2024Enrolled20ConditionsDiabetes Mellitus, Type 2, Periodontitis, Adult, PeriodontitisArmsControl (C) - Saline Gel, Test (t) - Photodynamic therapy and 2% chlorexidine and 0,005% methylene blue
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Stefano CorbellaDepartment of Biomedical, Surgical and Dental Sciences, Università degli Studi di Milano, Milan, Italy. stefano.corbella@gmail.com.
Elena CalciolariCentre for Oral Clinical Research Institute of Dentistry, Barts and The London, School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Nikolaos DonosCentre for Oral Clinical Research Institute of Dentistry, Barts and The London, School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Alice AlbertiDepartment of Biomedical, Surgical and Dental Sciences, Università degli Studi di Milano, Milan, Italy.
Pinar ErcalCentre for Oral Clinical Research Institute of Dentistry, Barts and The London, School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Luca FrancettiDepartment of Biomedical, Surgical and Dental Sciences, Università degli Studi di Milano, Milan, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesPeriodontal disease and diabetes have an extensively investigated bidirectional correlation. Non-surgical periodontal treatment (NSPT) was proven to contribute to glycemic control. Moreover, it may benefit from the association of adjunctive therapies. The aim of the present systematic review is to assess the clinical efficacy of NSPT in association with laser (LT) or photodynamic therapy (PDT) in controlled or uncontrolled diabetic patients, and to grade the level of evidence. MATERIALS AND

methodsRandomized controlled clinical trials with at least 3-month follow-up were searched in MEDLINE via OVID, EMBASE, and Cochrane Central, screened for inclusion, and grouped based on the performed treatments, follow-up time, type of diabetes, and level of glycemic control.

resultsEleven RCTs with 504 total subjects were included. The adjunct of PDT showed a statistically significant 6-month difference in PD changes (with low certainty of evidence), but not in CAL changes, while a significant difference in 3-month PD and CAL changes was found with the adjunct of LT (low certainty of evidence). Patients treated with PDT registered a higher decrease in HbA1c levels at 3 months, but no significant difference was noted at 6 months; LT also led to better HbA1c changes at 3 months with a moderate certainty of evidence.

conclusionDespite the promising short-term HbA1c decrease, the results should be interpreted with caution due to the small effect sizes and the statistical heterogeneity, and further evidence from well-designed RCTs is needed to support the routine use of PDT or LT in adjunct to NSPT.

Indexed as

Chronic PeriodontitisDiabetes Mellitus, Type 2Periodontal DiseasesPeriodontitisPhotochemotherapyDental ScalingGlycated HemoglobinHumansGlycated HemoglobinAntimicrobial photodynamic therapyDiabetes mellitusLaserNon-surgical periodontal treatmentPeriodontitisSystematic review

Identifiers

PMID36849595
PMCPMC10101891

What Socratic holds

Textmetadata
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.